Publications

Lee, S., Chen, T.T., Barber, C.L., Jordan, M.C., Murdock, J., Desai, S., Ferrara, N., Nagy, A., Roos, K.P. and Iruela-Arispe, M.L.. 2007. Autocrine VEGF Signaling Is Required for Vascular Homeostasis. Cell 130: 691-703 .

Hofmann, J.J., Iruela-Arispe, M.L.. 2007. Notch signaling in blood vessels: who is talking to whom about what? Circulation Res 100: 1556-1568 .

Hellstrom, M., Phng, L.K., Hofmann, J.J., Wallgard, E., Coultas, L., Lindblom, P., Alva, J., Nilsson, A.K., Karlsson, L., Gaiano, N., Yoon, K., Rossant, J., Iruela-Arispe, M.L., Kalen, M., Gerhardt, H., Betsholtz, C.. 2007. Dll4 signalling through Notch1 regulates formation of tip cells during angiogenesis Nature 445: 776-80 .

Lee, M., Chen, T.T., Iruela-Arispe, M.L., Wu, B.M., Dunn, J.C.. 2007. Modulation of protein delivery from modular polymer scaffolds. Biomaterials 28: 1862-70 .

Hofmann, J.J. and Iruela-Arispe M.L.. 2007. Notch expression patterns in the retina: An eye on receptor-ligand distribution during angiogenesis. Gene Expr Patterns 7: 461-70 .

Lee, S. and Iruela-Arispe, M.L.. 2007. The Extracellular Matrix and VEGF Processing Anti-Angiogenesis, 2nd edition : 461-70 .

Yang, L.V., Radu, C.G., Roy, M., Lee, S., McLaughlin, J., Teitell, M.A., Iruela-Arispe M.L. and Witte, O.N.. 2006. Vascular abnormalities in mice deficient for the G protein-coupled receptor GPR4 that functions as a pH sensor. Mol Cell Biol 27: 1334-1347 .

Hashimoto-Partyka, M., Lydon, J., and Iruela-Arispe, M.L. 2006. Generation of a mouse for conditional excision of progesterone receptor (PRCE) Genesis 44: 391-395 .

Lee, N.V., Sato, M., Annis, D.S., Loo, J.A., Wu, L., Mosher, D.F. and Iruela-Arispe, M.L. 2006. ADAMTS1 mediates the release of anti-angiogenic polypeptides from TSP1 and TSP2 The EMBO J 25: 5270-5283 .

Monvoisin, A., Alva, J.A., Hofmann, J.J., Zovein, A.C., Lane, T.F., and Iruela-Arispe, M.L. 2006. VE-cadherin-CreER(T2) transgenic mice: A model for inducible recombination in the endothelium Dev. Dyn 235: 3413-3422 .

Torres-Collado, A.X., Kisiel, W., Iruela-Arispe, M.L., Rodriguez-Manzaneque, J.C. 2006. ADAMTS1 interacts with, cleaves and modifies the extracellular location of the matrix inhibitor tissue factor pathway inhibitor-2 (TFPI-2) J Biol Chem 281: 17827-17837 .

Kern, C.B., Twal, W.O., Mjaatvedt, C.H., Fairey, S.E., Toole, B.P., Iruela-Arispe, M.L., Argraves, W.S. 2006. Proteolytic cleavage of versican during cardiac cushion morphogenesis Dev Dyn 235: 2238-2247 .

Alva, J.A., Zovein, A.C., Monvoisin, A., Murphy, T., Salazar, A., Harvey, N.L., Carmeliet, P. and Iruela-Arispe, M.L.. 2006. VE-Cadherin-Cre-recombinase transgenic mouse: A tool for lineage analysis and gene deletion in endothelial cells Dev Dyn 235: 759-767 .

Barber, C.L., and Iruela-Arispe, M.L.. 2006. The ever-Elusive Endothelial Progenitor Cell: Identities, Functions and Clinical Implications Pediatr Res 59: 26R-32R .

Iruela-Arispe, M.L.. 2006. When it comes to lymphatics, it is all a question of time Am J. Pathol 169: 347-350 .

Zovein, A.C. and Iruela-Arispe, M.L.. 2006. My O'Myeloid, a tale of two lineages PNAS 29103: 12959-12960 .

Lee, N.V. and Iruela-Arispe, M.L.. 2006. Thrombospondins and Angiogenesis Tumor Angiogenesis: Mechanisms and Cancer Therapy : 12959-12960 .

Krampert, M., Kuenzle, S., Thai, S.N., Lee, N., Iruela-Arispe, M.L., Werner, S. 2005. ADAMTS1 proteinase is upregulated in wounded skin and regulates migration of fibroblasts and endothelial cells J Biol Chem 280: 23844-23852 .

Lee, S., Jilani, S.M. Nikolova, G.V., Carpizo, D., and Iruela-Arispe, M.L. 2005. Processing of VEGF-A by matrix metalloproteinases regulates bioavailability and vascular patterning in tumors J Cell Biol 169: 681-691 .

Cho, H.M., Rosenblatt, J.D., Kang, Y.S., Iruela-Arispe, M.L., Morrison, S.L., Penichet, M.L., Kwon, Y.G., Kim, T.W., Webster, K.A., Nechustan, H. and Shin, S.U.. 2005. Enhanced inhibition of murine tumor and human breast tumor xenografts using targeted delivery of an antibody-endostatin fusion protein Mol Cancer Ther 4: 956-967 .

Lee, N.V., Rodriguez-Manzaneque, J.C., Thai, S.N., Twal, W.O., Luque, A., Lyons, K.M., Argraves, W.S., Iruela-Arispe, M.L. 2005. Fibulin-1 acts as a cofactor for the matrix metalloprotease ADAMTS-1 J Biol Chem 280: 34796-34804 .

Iruela-Arispe, M.L.. 2005. Vascular Development and Angiogenesis Encyclopedia of Molecular Cell Biology and Molecular Medicine : 34796-34804 .

Calzada, M.J., Zhou, L., Sipes, J.M., Zhang, J., Krutzsch, H.C., Iruela-Arispe M.L., Annis, D.S., Mosher, D.F., Roberts, D.D.. 2004. Alpha4 Beta1 Integrin Mediates Selective Endothelial Cell Responses to Thrombospondins 1 and 2 In Vitro and Modulates Angiogenesis In Vivo Circ Res 94: 462-470 .

Fiala, M., Murphy, T., MacDougall, J., Yang, W., Luque, A., Iruela-Arispe, L., Cashman, J., Buga, G., Byrns, R.E., Barbaro, G., Arthos, J.. 2004. HAART drugs induce mitochondrial damage and intercellular gaps and gp120 causes apoptosis Cardiovasc Toxicol 4: 327-337 .

Iruela-Arispe, M.L.. 2004. Angiogenesis: novel and basic science insights and human therapy - keystone symposium IDrugs 7: 111-113 .

Iruela-Arispe, M.L., Luque, A. and Lee, N.. 2004. Thrombospondin modules in Angiogenesis Int. Journal of Biochemistry and Cell Biol 36: 1070-1078 .

Alva, J.A. and Iruela-Arispe, M.L.. 2004. Notch Signaling in Vascular Morphogenesis Current Opinion in Hematology 11: 278-293 .

Thomas-Tikkonenko, A. and Iruela-Arispe, M.L.. 2004. Whence Thrombospondin? Cancer Biology and Therapy 3: e60-e61 .

Jilani SM, Murphy TJ, Thai SN, Eichmann A, Alva JA, Iruela-Arispe ML. 2003. Selective binding of lectins to embryonic chicken vasculature J Histochem Cytochem : 597-604 .

Iruela-Arispe, M.L., Carpizo, D., Luque, A.. 2003. ADAMTS1: a matrix metalloprotease with angioinhibitory properties Ann N Y Acad Sci 995: 183-190 .

Ellwood-Yen K, Graeber TG, Wongvipat J, Iruela-Arispe ML, Zhang J, Matusik R, Thomas GV, Sawyers CL. 2003. Myc-driven murine prostate cancer shares molecular features with human prostate tumors Cancer Cell 4: 223-238 .

Murayama, Y., Vinuela, F., Tateshima, S., Gonzalez, N.R., Song, J.K., Mahdavieh, H., Iruela-Arispe, M.L.. 2002. Cellular responses of bioabsorbable polymeric material and Guglielmi detachable coil in experimental aneurysms Stroke 33: 1120-1128 .

Iruela-Arispe, M.L. and Graubert, M.D.. 2002. Vascular endothelial growth factor, transforming growth factor alpha and estrogen receptors: possible cross-talks and interactions Am. J. Pathol. 160: 381-383 .

Rogriguez-Manzaneque, J.C., Westling, J., Thai, S.N., Luque, A., Knauper, V., Murphy, G., Sandy, J.D., and Iruela-Arispe, M.L.. 2002. ADAMTS1 cleaves aggrecan at multiple sites and is differentially inhibited by metalloproteinase inhibitors Biochem. and Biophys. Res. Comm. 293: 501-508 .

Thai, S.N.M. and Iruela-Arispe, M.L.. 2002. Expression of ADAMTS1 during murine development Mechanisms of Development 115: 181-185 .

Adams, J.Y., Johnson, M., Sato, M., Berger, F., Gambhir, S.S., Carey, M., Iruela-Arispe, M.L. and Lily, Wu. 2002. Visualization of advanced human prostate cancer lesions in living mice by a targeted gene transfer vector and optical imaging Nature Med. 8: 891-897 .

Gaspar, J., Thai, S., Voland, C., Dube, A., Libermann, T.A., Iruela-Arispe, M.L. and Oettgen, P.. 2002. Oppiosing functions of the Ets factors NERF and ELF-1 in the regulation of the Tie genes during chicen blood vessel development Art. Throm. and Vasc. Biol. 22: 1106-1112 .

Park H.J., Kong D., Iruela-Arispe M.L., Begley U, Tang D, Galper J.B.. 2002. 3-hydroxy-3methylglutaryl coenzyme A reductase inhibitors interfere with angiogenesis by inhibiting the geranylgeranylation of RhoA Circ Res 91: 143-150 .

Graubert, M.D., Ortega, M.A., Kessel, B., Mortella, J.F. and Iruela-Arispe, M.L.. 2001. Vascular repair after menstruation involves regulation of vascular endothelial growth factor-receptor phosphorylation by sFLT-1 Am. J. Pathol. 158: 1399-1410 .

Dube, A., Thai, S., Gaspar, J., Rudders, S., Iruela-Arispe, M.L., and Oettgen, P.. 2001. ELF-1 is a transcriptional regulator of the Tie-2 gene during vascular development Circ. Res. 88: 237-244 .

Sandy, J.D., Westling, J., Kenagy, R.D., Iruela-Arispe, M.L., Verscharen, C., Rodriguez-Manzaneque, J.C., Zimmerman, D., Lemire, J.M., Fischer, J.W., Wight, T.N and Clowes, A.W.. 2001. Versican V1 proteolysis in human aorta in vivo occurs at the Glu441-Ala442 bond, a site which is cleaved by recombinant ADAMTS-1 and ADAMTS-4 J. Biol. Chem. 276: 13372-13378 .

Iruela-Arispe, M.L., Ortega, M.A., Oikemus, S. and Pepper, M.S.. 2001. Vascular morphogenesis in the mammary gland - introduction and overview. Vascular Morphogenesis in the Female Reproductive System. : 13372-13378 .

Saaristo, A., Karkkainen, M.J., Alitalo, K., Montesano, R., Iruela-Arispe, M.L., Pepper, M.S.. 2001. Growth factor regulation of physiological angiogenesis in the mammary gland. Chapter in: Vascular Morphogenesis in the Female Reproductive System. : 13372-13378 .

Augustin, H.G., Iruela-Arispe, M.L., Rogers, P., and Smith, S.. 2001. Vascular Morphogenesis in the Female Reproductive System Springer-Birkhaeuser, New York : 13372-13378 .

Villa, N., Walker, L., Lindsell, C.E., Gasson, J., Iruela-Arispe, M.L. and Weinmaster, G.. 2001. Vascular expression of Notch pathway receptors and ligands is restricted to arterial vessels Mechanisms of Development 108: 161-164 .

Rodriguez-Manzaneque, J.C., Lane, T.F., Ortega, M.A., Hynes, R.O., Lawler, J., and Iruela-Arispe, M.L.. 2001. Thrombospondin-1 suppresses tumor growth by a novel mechanism that includes blockade of matrix metalloproteinase-9 activation PNAS : 12485-12490 .

Rodriguez-Manzaneque, J.C., Graubert, M., and Iruela-Arispe, M.L.. 2000. Vascular Dysfunction by prolonged activation of progesterone receptor Human Reproduction : 12485-12490 .

Chandrasekaran, L., He, Z.C., Al-Barazi, H., Krutzch, H.C., Iruela-Arispe, M.L., and Roberts, D.D.. 2000. Cell contact-dependent activation of a3b1 intergrin modulates endothelial cell responses to thrombospondin-1 Mol. Biol. Cell. : 12485-12490 .

Lee S.W., Reimer, C.L., Fang, L., Iruela-Arispe, M.L. and Aaronson, S.A.. 2000. Overexpression of kinase-associated phosphatase (KAP) in breast and prostate cancer inhibition of the transformed phenotyhpe by antisense KAP expression Molec. & Cell. Biol. 20: 1723-1732 .

Pepper, M.S., Baetens, D., Mandroita, S.J., Di Sanza, C., Oikemus, S., Lane, T.F., Soriano, J.V., Orci, L., Montesano, R., Iruela-Arispe, M.L.. 2000. Regulation of VEGF and VEGF receptor expression in rodent mammary gland during pregnancy, lactation and involution Dev. Dynamics 218: 507-524 .

Streit, M., Valesco, P., Riccardi, L., Richard, L., Brown, L.F., Janes, L., Lange-Asschenfeldt, B. ,Yano, K., Hawighorst, T., Iruela-Arispe, M.L., and Detmar, M.. 2000. Thrombospondin-1 suppresses wound healing and granulation tissue formation in the skin of transgenic mice The EMBO Journal 19: 3272-3282 .

Rodriguez-Manzaneque, J.C., Milchanowski, A.B., Dufour, E.K., Leduc, R., and Iruela-Arispe, M.L.. 2000. Characterization of Meth-1/Adamts-1 processing reveals two distinct active forms J. Biol. Chem. 275: 33471-33479 .

Pal, S., Iruela-Arispe, M.L., Harvey, V.S., Zeng, H., Nagy, J.A., Dvorak, H.F. and Mukhopadhyay, D.. 2000. Retinoic acid selectively inhibits the vascular permeabilizing effect of VPF/VEGF, an early step in the agiogenic cascade Microvasc. Res. 60: 112-120 .

Carpizo, D. and Iruela-Arispe, M.L.. 2000. Endogenous regulators of angiogenesis - Emphasis on proteins with thrombospondin - type I motifs Cancer and Metastasis Reviews 19: 159-165 .

Vazquez, F., Rodriguez-Manzaneque, J.C., Lydon, J.P., Edwards, D.P., O'Malley B.W., and Iruela-Arispe, M.L.. 1999. Progesterone regulates proliferation of endothelial cells J. Biol. Chem. 274: 2185-2192 .

Dhanabal, M., Ramchandran, R., Volk, R., Stillman, I.E., Lombardo, M., Iruela-Arispe, M.L., Simons, M., and Sukhatme, V.P.. 1999. Endostatin: yeast production, mutants, and anti-tumor effect in renal cell carcinoma Cancer Res. 59: 189-197 .

Iruela-Arispe, M.L., Rodriguez- Manzaneque, and Abu-Jawdeh, G.. 1999. Endometrical endothelial cells express estrogen and progesterone receptors and exhibit a tissue specific response to antiogenic growth factors Microcirculation 6: 127-140 .

Brown, L.F., Guidi, A.J., Schnitt, S.J., Van De Water, L., Iruela- Arispe, M.L., Yeu, T.K., Tognassi, K., Dvorak, H.F.. 1999. Vascular stroma formation in carcinoma in situ, invasive carcinoma, and metastatic carcinoma of the breast Clin. Cancer Res. 5: 1041-1056 .

Zhai, Y., Yu, L., Iruela- Arispe, L., Huang, W.Q., Wang, Z., Hayes, A.J., Lu, J., Jaing, G., Rojas, L., Lippman, M.E., Ni, J., Yu, G.L., and Li, L.Y.. 1999. Inhibition of angiogenesis and breast cancer xenograft tumor by VEGI, a novel cytokine of the TGF superfamily Int. J. Cancer 82: 131-136 .

Vazquez, F., Hasting, G., Ortega, M.A., Lane, T.F., Oikemus, S., Lombardo, M., and Iruela-Arispe, M.L.. 1999. METH1 a human ortholog of ADAMTS, and METH2 are members of a new family of proteins with angio-inhibitory activity J. Bio. Chem. 274: 22349-22357 .

Wu. H., Lee, S.H., Jing Gao, Xin Liu, and Iruela-Arispe, M.L.. 1999. Inactivation of erythropoetin leads to defects in cardiac morphogenesis Development 126: 3597-3605 .

Iruela-Arispe, M.L., Lombardo, M., Krutzsch, H.C., Lawler, J., and Roberts, D.D.. 1999. Inhibition of angiogenesis by thrombospondin-1 is mediated by two independent regions within the type1 repeats Circulation 100: 1423-1431 .

Iruela-Arispe, M.L., Vazquez, F., and Ortega, M.A.. 1999. Anti-angiogenic domains shared by thrombospondins and metallospondins, a new family of angiogenic inhibitors Ann. N.Y. Acad. Sci. 886: 58-66 .

Iruela-Arispe, M.L., Ortega, M.A., and Vazquez, F.. 1999. Anti-angiogenic domain of thrombospondin Angiogenesis in Health and Disease: Basic Mechanisms and Clinical Applications : 58-66 .

Brown, L.F., Demar, M., Tognazzi, K., Abu-Jawdeh., G. and Iruela-Arispe, M.L.. 1997. Uterine smooth muscle cells express functional receptors (flt-1 and KDR) for vascular permeability factor (vascular endothelial growth factor) Lab. Invest. 76: 245-255 .

Iruela-Arispe, M.L.. 1997. Normal placentation: A tale that requires an epithelial-to-endothelial conversion J. Clin.Invest. 99: 2057-2058 .

Iruela-Arispe, M.L.. 1997. Angiogenesis: A dynamic balance of stimulator and inhibitors Thromb. Haem. 78: 672-677 .

Lee, S.H., Little, C.D. and Iruela-Arispe, M.L.. 1997. Proliferation and differentiation of smooth muscle cell precursors occors simultaneously during the development of the vessel wall Dev. Dyn. 209: 342-352 .

Iruela-Arispe, M.L., Porter, P., Borstein, P., and Sage E.H.. 1996. Thrombospondin-1, an inhibitor of angiogenesis, is regulated by progesterone in human stromal cells J. Clin. Invest. 97: 403-412 .

Gariano, R.F., Iruela-Arispe M.L., Sage, E. H., and Hendrickson, A.E.. 1996. Immunohistochemical characterization of developing and mature primate retinal blood vessals Invest. Ophthalmol. & Visual Science 37: 93-103 .

Wu, H., Jaenish, R., and Sage, E.H.. 1996. Type 1 collagen-depleted mov 13 mice fail to assemble functional extracellular matrix Dev. Dyn. 207: 171-183 .

Luther, T., Flossel, C., Mackman, N., Bierhaus, A., Kasper, M., Albrecht, S., Sage, E.H., Iruela-Arispe, L., Grossmann, H., Strohelein, A., Zhang, Y.. 1996. Tissue factor expression during human and mouse development Am. J. Pathol. 149: 101-113 .

Iruela-Arispe, M.L., Lane, T.F., Redmond, D., Reilly, M., Bolender, R., and Kavanaugh, T.J. and Sage E.H.. 1995. Expression of SPARC during the development of the chorioallantoic membrane: protein degradation produces angiogenic peptides Mol. Biol. Cell 6: 327-343 .

Vernon, R. B., Wight, T.N., Lara, S., Iruela-Arispe, M.L., Angello J.C., and Sage, E.H.. 1995. Tesselated networks of endothelial cells that arise spontaneously in vitro are associated with traction-generated templates of type1 collagen Cell Dev. Biol. 31: 120-131 .

Seiffert, D., Iruela-Arispe, M.L., Sage, E.H., and Loskutoff, D.J.. 1995. Distribution of vitronectin mRNA during murine development Dev. Dyn. 203: 71-79 .

Reed, M.J., Iruela-Arispe, M.L., O' Brein, E.R., Truong, T., LaBell, T., Borstein, P., and Sage E.H.. 1995. Expression of thrombospondins by endotheial cells: injury is correlated with TSP1 Am. J. Pathol. 147: 1068-1080 .

Iruela-Arispe, L., Gordon, K., Hugo, C., Duijvestijn, A. M. Claffey, K.P., Reilly, M., Couser, W. G., Alpers, C.E. and Johnson, R.J.. 1995. Participation of glomerular endotheial cells in the capillary repair of glomerulonephritis Am. J. Pathol. 147: 1715-1728 .

Iruela-Arispe, M.L.,Liska, D.A., Sage, E.H. and Borenstein, P.. 1994. Differential of Expression of Thrombospondin 1, 2, an 3 during Murine Development Dev. Dyn. 197: 40-56 .

Battegay, E. J., Rupp, J., Iruela-Arispe, M.L., Sage, E.H., and Pech, M.. 1994. PDGF-BB modulates endothelial proliferation and angiogenesis in vitro via PDGFB-receptors, J. Cell Biol. 125: 917-928 .

Lane, T.F., Iruela-Arispe, M.L., Johnson, R.S. and Sage, E.H.. 1994. SPARC is a source of copper-binding peptides the stimulate angiogenesis J. Cell Biol. 125: 929-943 .

Gariano, R.F., Iruela-Arispe, M.L. and Hendrickson, A.E.. 1994. Vascular Development in the primate retina: Comparison of laminar plexus formation in monkey and human Invest. Ophtal. Vis. Sci. 35: 3442-3455 .

Iruela-Arispe, M.L., and Sage, E.H.. 1993. Endothelial Cells Exhibiting Angiogenesis in vitro Proliferate in Response to TGF-B1 J. Cell. Biochem. 52: 414-430 .

Bassuk, J.A., Iruela-Arispe, M.L., Lane, T.F., Berg, R.A., and Sage, E.H.. 1993. Molecular analysis of chicken embryo SPARC Europ. J Biochem. 218: 117-127 .

Raines, E.W., Lane, T., Iruela-Arispe, M.L.,Ross, R., and Sage, E.H.. 1992. The Extracellular Glycoprotein SPARC Interacts with Platelet-derived Growth Factor (PDGF)-AB and BB and Inhibits Binding of PDGF to its Receptor Proc. Natl.Acad. Sci. 89: 1281-1285 .

Iruela-Arispe, M.L., Chun, L., and Sage, E. H.. 1992. Structure and Biology of Type 8 Collagen Trends Glycosci. Glycotechnol. 4: 188-199 .

Vernon R.B., Angello, J.C., Iruela-Arispe, M.L., Lane, T.F., and Sage E.H.. 1992. Reorganization of Basement Membrane Matrices by Cellular Traction Promotes the Formation of Cellular Networks in vitro Lab. Invest. 66: 536-547 .

Lane, T., Iruela-Arispe, M.L. and Sage, E.H.. 1992. Regulation of Gene Expression by SPARC during Angiogenesis in vitro: Changes in Fibronectin, Thrombospondin- 1, and Plasminogen Activator Inhibitor- 1 J. Bio. Chem. 267: 16736-16745 .

Sage, E.H., Lane, T.F., Iruela-Arispe, M.L. and Funk, S.E.. 1992. A Protein that Modulates Cell Cycle and Cell-matrix Interactions Proc. Forth Int'l Conf. Chem. Biol. Mineraliz. Tiss. : 235-242 .

Javelainen, H.T., Iruela-Arispe, M.L., Sandell, L.J., Sage, E.H., and Wight, T.N.. 1992. Modulation of Decorin, Biglycan and Type 1 Collegen Synthesis by Sprouting Bovine Aortic Endothelial Cell Cultures Exp. Cell Res. 203: 395-401 .

Floege, J., Johnson, R.J., Gordon, K., Yoshimura, A., Campell, C., Iruela-Arispe, M.L., Alpers, C.E., Couser, W.G.. 1992. Altered Glomerular Extracellular Matrix Synthesis in Experimental Membranous Nephropathy: Studies in Two Models and Cultures Glomerular Epithelial Cells Kidney Int. 42: 573-585 .

Paulus, W., Sage, H., Iruela-Arispe, M.L. and Liszka, U.. 1991. Selective Expression of Type 8 Collagen in Tumors of the Human Brain Brit. J. Cancer 63: 367-371 .

Iruela-Arispe, M.L., and Sage, H.. 1991. Expession of Type 8 Collagen during Morphogenesis of the Chicken and Mouse Heart Dev. Biol. 144: 107-118 .

Iruela-Arispe, M.L., Bornstein, P., and Sage, H.. 1991. Thrombospondin Exerts an Antiangiogenic Effect on Tube Formation by Endothelial Cells in vitro Proc. Natl. Acad. Sci. 88: 5026-5030 .

Fouser, L., Iruela-Arispe, M.L., Borstein, P., and Sage, E.H.. 1991. Transcriptional Activity of the I (1) Collagen Promoter in Endothelial Cells is Correlated with Angiogenesis in vitro J. Biol. Chem. 88: 18345-18351 .

Iruela-Arispe, M.L., Diglio, C.A. and Sage, E.H.. 1991. Modulation of Extracellular Matrix Proteind by Endothelial Cells undergoing Angiogenesis in vitro Arterioscler. Thromb 11: 805-815 .

Sage, H. and Iruela-Arispe, M.L.. 1990. Type 8 Collagen in Murine Development. Association with Capillary Formation in virto Structure, Molecular Biology and Pathology of Collagen. 580: 17-31 .

Iruela-Arispe, M.L. Hasselaar, P., Sage, H.. 1990. Differential Expression of Extracellular Proteins is correlated with Angiogenesis in vitro Lab. Invest. 64: 174-186 .

Cotta-Pereira, G. and Iruela-Arispe, M.L.. 1989. Extracellular matrix: Functional significance of oxytalan, elaunin and elastic fibers Cells and Tissues: A ThreeDimensional Approach by Modern Techniques in Microscopy. : 61-67 .

Chow, M., Boyd, C.D., Iruela-Arispe, M.L., Wrenn, D.S., Mecham, R., and Sage, H.. 1989. Characterization of Elastin Protein and mRNA from Salmonid Fish (Oncorhynchus kisutch) Comp. Biochem. Physiol. 93: 835-845 .

Sage, H., Vernon, R.D., Decker, J., Funk, S., and Iruela-Arispe, M.L.. 1989. Distribution of the Calcium-binfing Protein SPARC in Tissues of Embryonic and Adult Mice J. Histochem. Cytochem. 37: 819-829 .