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We are taking various approaches to better understand hematopoietic development in Drosophila. This icludes identifying new markers of various cell populations within the lymph gland as well as attempting to determine the lineage relationships between these populations. Recently, work in the lab has identified various transcription factors and signal transduction pathways that influence hematopoiesis. We would like to continue in this process in order to understand Drosophila blood development and how it is similar and different from vertebrate hematopoiesis.

The lymph gland is formed during embryogenesis and is the site of larval hematopoiesis.

One of our goals is to identify new markers for various cell populations in the lymph gland.

The anterior larval lymph gland lobes expressing GFP that marks cell membranes.

Crystal cells are one major type of hemocyte observed in Drosophila. This cell expresses GFP in the cytoplasm, with the nucleus stained for lacZ (red) and DNA (blue). The paracrysalline inclusions appear as dark voids.

Hemocytes from the larval lymph gland.

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