For Further Information
Please Contact
Amander Clark
clarka@ucla.edu

 



Selected Publications

 

Book Chapters:

Fox, M, Reijo Pera, RA, and Clark, A.T. The DAZ gene family and human germ cell development from embryonic stem cells In. ‘The Sperm Cell’ ed. De Jong, C & Barratt, C Cambridge University Press, 2006, Chapter 12.

 

Original Articles:

2008

Conway, AE., Lindgren, A., Galic, Z., Pyle, D., Wu, H., Zack, J., Pelligrini, M., Teitell, MA., Clark, AT. (2008) A Pluripotency and Self-Renewal Program Controls the Expansion of Genetically Unstable Cancer Stem Cells in Pluripotent Stem Cell-Derived Tumors. Stem Cells Epub September

Ambartsumyan GA, Clark, AT. (2008) Aneuploidy and early human embryo development Human Molecular Genetics 17: R10-5

Hao, W., Kim, K., Mehta, K., Paxia, S., Sundstrom, A., Anantharamen, T., Ali, K., Doan, T., Ghosh, J., Pyle, A., Clark, AT., Lowry, WE., Fan, G., Baxter, T., Mishra, B., Sun, Y., Teitell, M (2008) Copy number variant analysis of human embryonic stem cells.  Stem Cells in press

Lowry, WE., Richter, L,. Yachechko, R., Pyle, AD., Tshieu, J., Sridharan, R., Clark, AT., Plath, K (2008) Generation of human induced pluripotent stem cells from dermal fibroblasts, PNAS Feb 26, 105(8):2883-2888

2007

Bostick, M., Kim, JK., Esteve, PO, Clark, AT, Pradhan, S and Jacobson, SE (2007) UHRF1 plays a role in maintaining DNA methylation in mammalian cells Science (2007) Aug 2; Epub ahead of print

Clark, AT (2007) Testicular Cancer Stem Cells. Stem Cell Reviews (2007); 3: 49-59

Fox, M., Clark, AT, Majdoubi, ME., Vigne, JL., Griswald, MD., Urano, J., Weiner, RI., Reijo Pera, RA (2007) Distinct RNA and Protein Complexes Distinguish Human and Mouse Embryonic Stem Cells and Germ Cells Dev Biol 302:417-431

2006 and Earlier

Kee, K., Gonsalves, JM., Clark, AT., Reijo Pera, RA (2006) Bone Morphogenetic Proteins Induce Germ Cell Differentiation from Human Embryonic Stem Cells. Stem Cells and Development 15; 831-837 .

Clark, AT* (2006) Establishment and Differentiation of Human Embryonic Stem Cell Derived Germ Cells. Reproduction suppl (in press).

Clark, AT* & Pera, RA (2006) Modeling Human Germ Cell Formation with Embryonic Stem Cells. Regenerative Medicine. 1(1); 85-93 *Corresponding author Download PDF

Ezeh, U, Turek, PJ, Reijo Pera, RA,  Clark, AT* (2005) Human Embryonic Stem Cell Genes NANOG, STELLAR and GDF3 are expressed in both Seminoma and Breast Cancer Cancer 104: 2255-2265. *Corresponding author Download PDF

Clark, A.T.  Bodnar, M., Fox, M., Rodriguez, R.T., Abeyta, M.J., Firpo, M.T., Reijo-Pera, R.A. (2004) Differentiation of the Human Germ Cell Lineage from Embryonic Stem Cells. Human Molecular Genetics 13(7):727-739. Download PDF

Abeyta, M.J., Clark, A.T. Rodriguez, R.T. Bodnar, M, Reijo-Pera, R.A. Firpo, M.T. (2004) Global Gene Expression in Human Embryonic Stem Cell Lines. Human Molecular Genetics 13(6):601-8. Download PDF

Clark, A.T. Rodriguez, R.T., Abeyta, M.J., Firpo, M.T., Reijo-Pera, R.A. (2004) Chromosome 12p13.1, a hot-spot for Teratocarcinoma, Encodes Three Genes Expressed in Pluripotent Cells with Remarkable Evolutionary Divergence from Humans to Mice Stem Cells 22(2) 169-179. Download PDF

Clark, AT. Clark AT, Goldowitz D, Takahashi JS, Vitaterna MH, Siepka SM, Peters LL, Frankel WN, Carlson GA, Rossant J, Nadeau JH, Justice MJ (2004). Large-scale ENU Mutagenesis Screens in North America. Genetica. Sep;122(1):51-64.
Download PDF

Clark, A.T., Firozi, K., Justice, M.J. (2004) Mutations in a Novel Locus on Mouse Chromosome 11 Resulting in Male Infertility Associated with Defects in Microtubule Assembly and Sperm Tail Function Biology of Reproduction  70:5; 1317-1324
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Kile B.T*, Hentges K.E*, Clark A.T*, Nakamura H, Salinger A.P, Liu B, Box N, Stockton D.W, Johnson R.L, Behringer R.R, Bradley A, Justice M.J. (2003) Functional Genetic Analysis of Mouse Chromosome 11. Nature. 4;425(6953):81-6. *denotes equal contribution. Download PDF

Clark, A.T., Young, R., Bertram, J.F. (2001). In vitro and Localization Studies on the Role of TGF-b1 in Rat Metanephric Development. Kidney International. 59:1641-1653.

Joyce I.M., Clark A.T., Pendola, F.L., Eppig J.J. (2000) Comparison of Recombinant Growth Differentiation Factor-9 and Oocyte Regulation of Kit Ligand Messenger Ribonucleic Acid Expression in Mouse Ovarian Follicles. Biology of Reproduction. 63(6):1669-1675.

Elvin J,A. Clark A,T., Wang, P., Wolfman N.M., and Matzuk M.M (1999). Paracrine Actions of Growth Differentiation Factor-9 in the Mammalian Ovary. Molecular Endocrinology, 13: 1035-1048.


 
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Live germ cells transfected with a DPPA3-fusion green fluorescent protein




Live germ cells transfected with a NANOG-fusion red fluorescent protein




Live germ cells showing overlay of fusion proteins, and intracellular localization