(10:40 minutes) click on the picture to view clip HHMI Professors Bob Goldberg, UCLA Teaching Non-Science Students About the Excitement of Discovery "All of us who have active research programs witness on a daily basis the excitement of discovery, and how rewarding and gratifying it is to make these discoveries ourselves. It is time to roll up our sleeves and infuse in our undergraduates the excitement all of us feel about science. If we do that, we will be able to train the innovative scientists and science-oriented citizens of tomorrow." In the Fall of 2002, Bob Goldberg was named one of 20 Howard Hughes Medical Institute Professors. HHMI created these awards to encourage research scientists to bring their creativity to the classroom to make science more engaging and captivating to undergraduates. Bob Goldberg has used HHMI funds to establish a novel undergraduate teaching program within the UCLA Honors Collegium, "Genetic Engineering for the Non-Science Major: Discovering Genes Required to Make a Seed," that targets non-science majors and entering life science students. His objective is to teach undergraduates about the excitement of discovery, the process by which science is carried out, how advances in biology affect our daily lives, and how science is taught. A lecture course has been created, HC70A - Genetic Engineering in Medicine, Agriculture, and Law, that provides the foundations of molecular biology, and discusses the ethical, legal, and social implications that result from emerging genomic technologies. This class is being taught to students at both UCLA and Kyoto University in Japan through a novel interactive, long-distance learning program that has allowed Bob Goldberg's HHMI Program to go "international." A lab class has also been created, HC70AL - Gene Discovery Lab, that provides an original research experience for students who have completed HC70A, and uses functional genomics to address the question of what are the genes required to make a seed? A novel aspect of HC70AL is that it provides non-science undergraduates an opportunity to learn first-hand how science is carried out and what scientists really do! Bob Goldberg's HHMI Program also gives undergraduates the opportunity to learn how to teach. Undergraduates actively participate in both HC70A and HC70AL as Teaching Fellows and Peer Research Mentors, providing a real-life classroom experience in teaching, mentoring, and educating their own students. Note: This web page is best viewed with the browser window maximized to fit the screen. If the video does not play, please download Quicktime 7 by clicking here for Mac or here for Windows. Please contact Brandon Le (ble@ucla.edu) if you have any problems with the videos.

COURSES DESIGNED FOR BOB GOLDBERG'S HHMI PROGRAM Honors Collegium 70A - Genetic Engineering in Medicine, Agriculture, and Law This course provides non-science majors and entering life science students with a foundation in molecular biology and genetics as it applies to genetic engineering, and addresses the social, legal, and ethical issues that arise from emerging new genetic technologies. This class is highly interactive, team-oriented, problem-based, and teaches students how to think critically about experimental science and the societal issues raised by advances in genetic engineering, genomics, and human reproduction. Over 150 undergraduates have taken this HHMI-sponsored course in the three years that it has been taught. Click here to browse the HC70A web site or click here to read the UCLA Honors Collegium HC70A course description. Honors Collegium 70AL - Gene Discovery Laboratory Undergraduates who have taken HC70A carry out an original, hands-on research project using state-of-the-art genomics technologies. Non-science students from majors as diverse as economics, communications, and classics team up with beginning life science students in an intense ten-week effort to identify genes that control seed development. Students use Arabidopsis as a model organism and identify knock-out mutations in genes known to be expressed during seed development. The Gene Discovery Laboratory teaches students who have never worked in a laboratory how to carry out an original research project and analyze data critically. At the end of the quarter, each student presents their results at an all-class symposium and is presented with a lab coat embroidered with their name. During the past three years, 38 students have participated in the HHMI-sponsored Gene Discovery Lab, and knock-outs in over 50 Arabidopsis genes have been identified and studied. Click here to browse the HC70AL web site or click here to read the UCLA Honors Collegium HC70AL course description Fiat Lux MCDB19 - Ethical Implications of Genetic Engineering HC70AL students participate in this seminar and use case studies to discuss research ethics and social implications of genetic engineering research. Click here for Fiat Lux web site. Honors Collegium 199 - Teaching Undergraduates How to Teach This informal course on the art of teaching is taken by undergraduates who serve as Teaching Fellows and Peer Laboratory Mentors in HC70A and HC70AL. Students learn how to develop a teaching "game plan," dissect and teach scientific papers, speak in front of a class, use the Socratic method as an interactive teaching tool, and gain the confidence and poise needed to teach their peers. Peer Laboratory Mentors also learn how to organize a teaching laboratory, demonstrate and teach genomics and bioinformatics procedures, and how to lead teams carrying out original research projects using functional genomics. In the past three years, 10 non-science and science undergraduates have participated as HHMI-sponsored Teaching Fellows and Peer Laboratory Mentors. ASSESSMENT Bob Goldberg's HHMI Program is being assessed in several ways. First, students evaluate HC70A and HC70AL at the end of each quarter as part of the UCLA course evaluation system. Second, a survey is conducted in HC70A on the first and last days of the quarter in order to compare student attitudes towards a range of genetic engineering issues. Third, students who have taken both HC70A and HC70AL are given a questionnaire that addresses the impact these classes have had on their academic career, their understanding of how science is carried out, and their view of the excitement of discovery. Fourth, each HC70AL student is given an exit interview to discuss the strengths and weaknesses of the lecture and laboratory components of Bob Goldberg's HHMI Program and how to improve the program. Finally, Bob Goldberg interviews the undergraduate teaching fellows and peer laboratory mentors to assess the impact that teaching HC70A and/or HC70AL has had on their future career goals and objectives. Sample Assessment Results Student evaluations have been excellent for the first three years that the HC70A course has been taught. For example, on a scale from 1-9 (1 low-9 high), the following ratings have been obtained for three sample questions: (1) 8.6, "your overall rating of the instructor;" (2) 8.6, "your overall rating of the course;" and (3) 8.7, "you have learned something you consider valuable." Other evaluation questions produced similar results. In addition, 36of the students stated that they had a "high interest in the subject matter before taking the course," while 80indicated that they had a high interest in the subject matter after taking the course! Click here to read the results of a survey given to the Winter, 2004 HC70A class on their attitude towards genetic engineering before and after they took the class. The impact that both HC70A and HC70AL has had on students that participated in the Gene Discovery Laboratory can be evaluated by reading the questionnaire filled out by the Spring, 2005 HC70AL students. Click here to read the results of this questionnaire. Sample statements from two former undergraduate teaching fellows, Mike Ferry and Malik Francis, who are now in Ph.D. Programs at UC San Diego and UC Berkeley, respectively, can be read by clicking here.

BOB GOLDBERG'S HHMI PROGRAM GOES INTERNATIONAL HC70A Winter 2004 - Teaching Without Borders (5:33 minutes) click on the picture to view clip If the video does not play, please download Quicktime 7 by clicking here for Mac or here for Windows. HC70AL Spring 2004 - Gene Discovery Laboratory, A Cultural and Scientific Collaboration (4:40 minutes) click on the picture to view clip If the video does not play, please download Quicktime 7 by clicking here for Mac or here for Windows. LONG DISTANCE LEARNING - BOB GOLDBERG'S HHMI PROGRAM GOES INTERNATIONAL Bob Goldberg's HHMI program is taught simultaneously to students at both UCLA and Kyoto University in Japan as part of a unique Trans-Pacific International Long-Distance Educational Program (TIDE). HC70A lectures and discussions are carried out in real time over a dedicated fiber optics cable using a state-of-the art classroom that allows simultaneous video and audio interactions between Bob Goldberg and his students on both sides of the Pacific Ocean - merging different cultures and universities into one large international classroom. UCLA and Kyoto students interact with each other, work in groups on an electronic blackboard, and participate in joint discussions and all-class projects. In addition, 10-20 students from each university "switch sides" for a week during the quarter - UCLA students go to Kyoto and participate from Japan and Kyoto University students visit UCLA and participate "live," providing for a novel cultural and educational experience. The HC70AL Gene Discovery Lab is also part of Bob Goldberg's HHMI-sponsored long-distance learning program. Kyoto University students that have completed HC70A visit UCLA for a quarter and team up with UCLA students in the laboratory using functional genomics to uncover genes required to make a seed. To date, approximately 75 UCLA and Kyoto University students have participated in the HC70A long-distance learning program, and 16 UCLA and Kyoto University students have teamed-up in the HC70AL Gene Discovery Laboratory. This unique HHMI-sponsored program demonstrates the power of high-tech long-distance learning and the impact of teaching an integrated course in different locations to students, including those with different cultures and languages. EDUCATIONAL RESOURCES DEVELOPED FOR UNDERGRADUATE RESEARCH HC70AL - Gene Discovery Laboratory Lab Manual A comprehensive week-by-week protocol book for students using genomics to study the function and activity of plant genes. Click on the link above to download the lab manual. (PDF size: 9 Mb) Gene Discovery Laboratory Web Notebook An interactive "web laboratory book" created to allow students real-time viewing of all experiments and results. Browse the "webbook" and view how students use this interactive web laboratory book to organize, summarize, and post their research results. The "webbook" program can be downloaded by clicking on the link above, and is freely available to anyone in the scientific community who would find it useful for their research and/or teaching. RELATED LINKS Bob Goldberg's Lab Web Site Honors Collegium 70A: Genetic Engineering in Medicine, Agriculture, & the Law Course Web Site Gene Discovery Laboratory Web Site Webbook: An Interactive Web Lab Notebook UCLA Honors Collegium Web Site

UNORTHODOX APPROACH TO TEACHING Bob Goldberg believes that teaching should be challenging, fast-paced, media oriented, and a collective - students interacting with students and students interacting with the professor - no matter how big the class might be. He does this by learning the names of his students, taking his students to weekly dinners, using the Socratic Method to engage and challenge students intellectually, calling on students in class to "design experiments", asking other students to challenge whether the experiment is "correct" or not, and by using guest speakers, films, and demonstrations that make science come "alive." Bob Goldberg uses a unique non-competitive team approach in his classes that encourages students to work together in teams, to be their own "professors," and to learn to think critically about how science is done rather than spitting back rote-memorized facts. Students in his classes take collective oral exams, work on take-home exams and quizzes together, perform in plays and docudramas that simulate "real-life" science-based situations, and carry out an all-class project that is filmed and presented on the last day of class. Bob Goldberg's classes are not classes, they are an experience! ARTICLES ON BOB GOLDBERG'S TEACHING AND HHMI PROGRAM Rising to the Challenge: Merging Research and Innovation for Undergraduate Science Education An article by Dan Gordon highlighting Bob Goldberg's undergraduate science education program funded by the Howard Hughes Medical Institute. Long Distance Learning An article from the UCLA Daily Bruin describing a multi-cultural long distance course taught by Professor Goldberg simultaneously to UCLA and Kyoto students in Japan using state-of-the-art fiber optic cables, electronic blackboards, and live audio and video hookups. Goldberg's Variation An article by Dan Gordon in the UCLA Magazine on Bob Goldberg's novel approach to teaching. To Teach or Not An editorial by Bob Goldberg in the journal The Plant Cell on undergraduate education. INDIVIDUALS THAT MAKE BOB GOLDBERG'S HHMI PROGRAM POSSIBLE Professor Bob Goldberg bobg@ucla.edu Dr. Anhthu Bui HHMI Program Senior Scientist, Instructor, and HC70AL Coordinator aqbui@ucla.edu Brandon Le HHMI Program HC70AL Instructor, Bioinformaticist, and Webmaster ble@ucla.edu Tomokazu Kawashima HHMI Program Graduate Instructor for HC70AL Peer Research Mentor tomokazu@ucla.edu Greta Nelson HHMI Program Administrator & Film Project Director (2002-2004) Jessica Luke HHMI Program Administrator (2004-present) jluke@mcdb.ucla.edu