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Honors Collegium 70A
Genetic Engineering in Medicine, Law, & Agriculture
Winter 2004
Professor Bob Goldberg
Course Documents
| Course Info: | ||||||
| Units: | 5.0 | |||||
| Lectures: | Tues & Thurs : 3:30 - 5:50 PM | |||||
| Discussions: | Wed : 2:00 - 3:50 PM Teaching Assistant Malik Francis Wed : 4:00 - 5:50 PM Teaching Assistant Mai Pham Wed : 6:00 - 7:50 PM Teaching Assistant Jinsun Choi Thurs : 6:00 - 7:50 PM Teaching Assistant Tomokazu Kawashima (Kyoto Class Discussion) |
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| Location: | Life Sciences 2320 | |||||
| Class Survey | A class survey was conducted on the first and last day of class concerning issues in genetic engineering. Click here to download survey questions and results. |
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| Class Syllabus | ||||||
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Class Handouts (The handout is separated into smaller files for easy download.) |
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Lecture Handout 1: The Age of DNA - What is Genetic Engineering? |
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Lecture Handout 2: What Are Genes? |
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Lecture Handout 3: How Do Genes Work? |
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Lecture Handout 3 Revised Part 2: How Detect Genes? |
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Lecture Handout 4: Nuts & Bolts of Genetic Engineering - The Factor VIII Story |
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Lecture Handout 5: 21st Century Applications of Genetic Engineering |
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Lecture Handout 6 & 7: Science & the Constitution |
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Lecture Handout 8 & 9: The Human Genome Project & Detecting Change in the Human Genome |
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Lecture Handout 10: Analysis of Variants in the Human Genome: Are There "Races"? |
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Lecture Handout 11: Genetics & the Law |
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| Articles For Discussion | ||||||
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Discussion One: The Basics of Genetic Engineering |
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Stanley N. Cohen |
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Michael D. Lemonick |
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Walter Isaacson et al., |
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Discussion Two: Using Genes and Genomics to Make Drugs |
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Walter Gilbert and Lydia Villa-Komaroff Useful Proteins From Recombinant Bacteria. Scientific American, April, 1980, 242 (4), 74-94. |
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William A. Haseltine Discovering New Genes For Medicine. Scientific American, March, 1997, 276 (3), 92-97. |
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Discussion Three: Using Animals and Plants as Drug Factories |
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William H. Velander, Henryk Lubon, and William N. Drohan Transgenic Livestock as Drug Factories. Scientific American, January 1997, 276 (1), 70-74. |
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Discussion Four: Identifying and Testing for Human Disease Genes |
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Ray White and Jean-Marc Lalouel
Chromosome Mappingwith DNA Markers. Scientific American , February, 1988, 258 (2), 40-48. |
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Discussion Five: Using DNA Testing in the Courtroom |
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Peter J. Neufeld and Neville Colman When Science Takes the Witness Stand. Scientific American, May, 1990, 262 (5), 46-53. |
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Jerry Adler and John McCormick The DNA Detectives. Newsweek, November 16, 1998, pg. 64-71 (public domain) |
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Barbara Murray and Brian Duffy Jefferson's Secret Life. U.S. News & World Report, November 9, 1998 (public domain). |
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Eugene A. Foster et al., Jefferson Fathered Slave's Last Child Nature, November 5, 1998, 396, 27-28, 1998. |
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Discussion Six: Embryonic Stem Cells and Cloning for Medicine |
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Roger A. Pedersen
Embryonic Stem Cells For Medicine. Scientic American, April, 1999, 280 (4), 68-73. |
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Jose B. Cibelli, Robert P. Lanza, Michael West, and Carol Ezzell
The First Human Cloned Embryo. Scientific American, January, 2002, 286 (1), 44-51. |
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Wendy Goldman Rohm
Seven Days of Creation: The Inside Story of a Human Cloning Experiment. Wired, January, 2004, 122-129. |
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Discussion Seven: Gene Therapy: Fixing Human Genetic Defects |
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Theodore Friedman
Overcoming the Obstacles to Gene Therapy. Scientific American, June, 1997, 276 (6), 96-101. |
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Steve Mirsky and John Rennie What Cloning Means for Gene Therapy? Scientific American, June, 1997, 276 (6), 122-123. |
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Discussion Eight: Understanding and Defeating Cancer |
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Webster K. Cavenee and Raymond L. White
The Genetic Basis of Cancer. Scientific American, March 1995, 273 (3), 72-79. |
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Dirk M. Nettelbeck and David T. Curiel Tumor-Busting Viruses. Scientific American, October, 2003, 289 (4), 68-75. |
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Stephen H. Friend and Roland B. Stoughton The Magic of Microarrays. Scientific American, February, 2002, 286 (2), 44-53. |
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Michael D. Lemonick and Alice Park New Hope For Cancer Time, May 28, 2001, pgs. 63-69. |
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Discussion Nine: Anthrax and Defending Against Bioweapons |
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Matthew S. Meselson
Chemical and Biological Weapons. Scientific American, May 1970, 222 (5), 15-25. |
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John T. Young and R. John Collier
Attacking Anthrax. Scientific American, March, 2002, 286 (3), 48-59. |
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Mark Williams, Stephen Herrera, and Philip Ross | ||||||