Honors Collegium 70A
Genetic Engineering in Medicine, Law, & Agriculture
Winter 2009


Professor Bob Goldberg

SPONORED BY



Course Documents

 
Course Info:
  Units: 5.0
  Lectures: Tues & Thurs : 3:30 - 6:00 PM
  Discussions: Wed : 12:00 - 2:00 PM TA Daisy Robinton (La Kretz 101)
Wed : 2:00 - 4:00 PM TA Aycha Erbilgin (La Kretz 101)
Wed : 4:30 - 6:30 PM TA Kelli Henry (LS 2320)
  Location: La Kretz 120
 
Class Syllabus
 

Class Handouts and Powerpoint Presentation

 

01/06/09 - Lecture-1 Handout(ppt): The Age of DNA: What is Genetic Engineering?

 

01/13/09 - Lecture-2 Handout(ppt): What Are Genes & How Do They Work: Part One

 

01/20/09 - Lecture-3 Handout(ppt): What Are Genes & How Do They Work: Part Two

 

01/27/09 - Lecture-4 Handout(ppt): The Nuts & Bolts of Genetic Engineering: The Factor VIII Story - From Gene To Drug

 

01/29/09 - Lecture-5 Handout(ppt): The Age of Genomics: Your Personal Genome

 

02/03/09 - Lecture-6 Handout(ppt): Identifying Human Origins: Past and Present

 

02/10/09 - Lecture-7 Handout(ppt): 21st Century Genetic Engineering Applications - Part I

 

02/17/09 - Lecture-8 Handout(ppt): 21st Century Genetic Engineering Applications - Part II

 

02/24/09 - Lecture-8.1 Handout(ppt): 21st Century Genetic Engineering Applications - Part III

 

03/03/09 - Lecture-9 Handout(ppt): Science and the Constitution: Regulating Science and Genetic Engineering

 

03/10/09 - Lecture-10 Handout(ppt): Science and the Constitution: Who Owns Your Genes?

 
Guest Speakers (Click on the name for information about the speaker)
  Dr. Richard Hamilton, Ph.D.
President and CEO, Ceres, Inc. Thousand Oaks, CA
Title: Engineering Plants For BioFuel Production [ppt - 11.6 MB]
  Dr. Alan McHughen, Ph.D.
CE Plant Biotechnologist, Department of Plant Sciences, UC Riverside
Title: GMOs: What's All The Fuss About? [ppt - 3.2 MB]

  Dr. Michele Evans, M.D., FACOG
Reproductive Specialist, Huntington Reproductive Center
Title: Infertility, In Vitro Fertilization (IVF), and Genetic Testing [ppt - 16.9 Mb]
  Dr. Russell Korobkin, J.D.
Professor, School of Law, UCLA
Title: Stem Cells: Ethical and Legal Issues [ppt - 786 Kb]
  Dr. John Novembre, Ph.D.
Assistant Professor, Department of Ecology and Evolutionary Biology, UCLA
Title: Tracking Human Ancestry [pdf - 6.8 Mb]
 
Articles For Discussion
 
Discussion One: The Basics of Genetic Engineering
   

Stanley N. Cohen
The Manipulation of Genes.
Scientific American, July, 1975, 233 (1), 24-33.

   
Clifford Grobstein
The Recombinant DNA Debate.
Scientific American, July, 1977, 237 (1) 22-33.
   
Berg et al.
Potential Biohazards of Recombinant DNA Molecules.
Science, New Series, Vol. 185, No. 4148 (Jul. 26, 1974), 303.
 
Discussion Two: Using Genetic Engineering to Make Drugs in Bacteria
   
Walter Gilbert and Lydia Villa-Komaroff
Useful Proteins From Recombinant Bacteria.
Scientific American, April, 1980, 242 (4), 74-94.
   
William A. Haseltine
Discovering Genes For New Medicine.
Scientific American, March, 1997, 276 (3), 92-97.
   
Ken Howard
The Bioinformatics Gold.
Scientific American, July 2000, 282 (1), 58-63.
 
Discussion Three: Using Genetic Engineering to Make Better Crops.
   
Charles S. Gasser and Robert T. Fraley
Transgenic Crops..
Scientific American, June, 1992, 266 (6), 62-69.
   
Terri Raney and Prabhu Pingali
Sowing a Gene Revolution..
Scientific American, September, 2007, 297 (3), 104-111.
   
Per Pinstrup-Anderson and Fuzhi Cheng
Still Hungry..
Scientific American, September, 2007, 297 (3), 96-103.
   
Kathryn Brown
Seeds of Concern..
Scientific American, April, 2001, 284 (4), 52-57.

Discussion Four: Identifying and Testing for Human Disease Genes
   
Ray White and Jean-Marc Lalouel
Chromosome Mapping with DNA Markers.
Scientific American , February, 1988, 258 (2), 40-48.
   
Mark A. Rothstein
Keeping Your Genes Private.
Scientific American , September, 2008, 299 (3), 64-69.
 
Discussion Five: DNA Testing in the Courtroom
   
Peter J. Neufeld and Neville Colman
When Science Takes the Witness Stand.
Scientific American, May, 1990, 262 (5), 46-53.
   
Jerry Adler and John McCormick
The DNA Detectives.
Newsweek, November 16, 1998, pgs.64-71.
   
 
Discussion Six: Genetic Engineering Farm Animals to Make Drugs
 
William H. Velander, Henryk Lubon, and William N. Drohan
Thansgenic Livestock as Drug Factories.
Scientic American, January, 1997, 276 (1), 70-74.
   
Ian Wilmot
Cloning For Medicine.
Scientific American, December 1998, 279 (6), 58-63.
   
Gary Stix
The Land of Milk & Honey
Scientific American, November 2005, 293 (5), 102-104.
 
Discussion Seven: Embryonic Stem Cell and Cloning for Medicine
   
Clive Cookson et al.,
The Future of Stem Cells..
Scientific American Special Report, July 2005, A6-A21.
   
Jose B. Cibelli, Robert P. Lanza, Michael West, and Carol Ezzell
The First Human Cloned Embryo.
Scientific American, January, 2002, 286 (1), 44-51.
   
Robin Marantz Henig
Pandora's Baby
Scientific American, June, 2003, 266 (6), 63-68. 
 
Discussion Eight: Understanding and Defeating Cancer
   
Webster K. Cavenee and Raymond L. White
The Genetic Basis of Cancer..
Scientific American, March 1995, 273 (3), 72-79.
   
Stephen H. Friend and Roland B. Stoughton
The Magic of Microarrays.
Scientific American, February, 2002, 286 (2), 44-53.
   
Francis S. Collins and Anna D. Barker
Mapping the Cancer Genome.
Scientific American, October, 2007, 296 (3), 50-57.
 
Discussion Nine: Tracing Human Origins
   
Gary Stix
Traces of a Distant Past.
Scientific American, July, 2008, 298 (6), 56-63.
   
Michael J. Bamshad and Steve E. Olsen
Does Race Exit?
Scientific American, December, 2004, 289 (6), 78-85.
 
Discussion Ten: Gene Therapy: Fixing Human Genetic Defects
   
   
Theodore Friedman
Overcoming the Obstacles to Gene Therapy.
Scientific American, June, 1997, 276 (6), 96-101.
   
Steve Mirsky and John Rennie
What Cloning Means for Gene Therapy?
Scientific American, June, 1997, 276 (6), 122-123.