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Molecular Basis of Vascular Biology (MCDB 224)

Spring Quarter 2005: Time: 10-10:50 in Room 2320 Life Sciences Bldg

Course Coordinators

Judith Berliner
JBerliner@mednet.ucla.edu
Office: 13-239 CHS
Extension: 5-2436 Luisa Iruela-Arispe
arispe@mbi.ucla.edu
Office: Boyer Hall 559
Extension: 4-5763

Requirements:

This is primarily a graduate course, however undergraduates may take this course with instructor approval. Graduate students should have taken 253 and either 267 or an equivalent course. Undergraduates should have comparable courses.

Grading:

1. Attendance (10%)
2. A paper critically analyzing a research article will be due by week 6 (40%)
3. Final exam: home-take exam (50%)

Course Syllabus

Week	Date	Topic	Instructor	Papers
1	4/5	Vascular Biology (overview)	(Arispe)	SUMMARY LECTURES 1 AND 2.
	4/7	Vascular Morphogenesis I	(Arispe)
2	4/12	Model systems to study vascular lineages (Drosophila)	(Banerjee)	PDF1, PDF2, PDF3
	4/14	Model systems zebra fish	(Chen)	PDF
3	4/19	Signaling Pathways in angiogenesis	(Chen)	PDF
	4/21	Role of angiogenesis in pulmonary pathology	(Strieter)	PDF1 PDF2 PDF3 PDF4 PDF5 PDF6 PDF7
4	4/26	Role of Angiogenesis in tumors	(Arispe)	PDF1 PDF2
	4/28	Hypoxia and angiogenesis	(Hankinson)
5	5/3	Stem cells in the Vascular System	(Bostrom)	PDF1 PDF2
	5/5	Leukocyte endothelial interactions	(Berliner)
6	5/10	Pathology of atherosclerosis (Introduction) and the role of the endothelium	(Berliner)	TBA
	5/12	Molecular genetics of human atherosclerosis	(Lusis)
7	5/17	The macrophage in atherosclerosis	(Edwards)	TBA
	5/19	A clinical view of atherosclerosis development	(Goldhaber)
8	5/24	A role for nuclear receptors in atherosclerosis	(Tontonoz)	TBA
	5/26	Molecular events in thrombosis	(Mackman)
9	5/31	Pathology of Vascular Amyloid	(Vinters)	TBA
	6/2	Vascular calcification	(Bostrom)
10		Final Exam