Karen M. Lyons Lab
UCLA Department of Molecular, Cell, and Developmental Biology
UCLA Department of Orthopaedic Surgery
UCLA Department of Orthopaedic Surgery
CTGF Inhibits BMP-7 Signaling in Diabetic Nephropathy.
Nguyen TQ, Roestenberg P, van Nieuwenhoven FA, Bovenschen N, Li Z, Xu L, Oliver N, Aten J, Joles JA, Vial C, Brandan E, Lyons KM, Goldschmeding R. J Am Soc Nephrol. 2008 Jul 16. In press.
A new model for growth factor activation: type II receptors compete with the prodomain for BMP-7.
Sengle G, Ono RN, Lyons KM, Bächinger HP, Sakai LY. J Mol Biol. 2008 Sep 12;381(4):1025-39. Epub 2008 Jul 2.
Cooperative Regulation of Chondrocyte Differentiation by CCN2 and CCN3 Revealed by a Comprehensive Analysis of the CCN Family Proteins in Cartilage.
Kawaki H, Kubota S, Suzuki A, Lazar N, Yamada T, Matsumura T, Ohgawara T, Maeda T, Perbal B, Lyons KM, Takigawa M. J Bone Miner Res. 2008 Jul 2. In press.
CCN2 (Connective Tissue Growth Factor) is essential for extracellular matrix production and integrin signaling in chondrocytes.
Nishida T, Kawaki H, Baxter RM, Deyoung RA, Takigawa M, Lyons KM. J Cell Commun Signal. 2007 Jun;1(1):45-58. Epub 2007 May 16.
The 5' untranslated regions (UTRs) of CCN1, CCN2, and CCN4 exhibit cryptic promoter activity.
Huang BL, Dornbach LM, Lyons KM. J Cell Commun Signal. 2007 Jun;1(1):17-32. Epub 2007 Mar 28.
Connective tissue growth factor is necessary for retinal capillary basal lamina thickening in diabetic mice.
Kuiper EJ, van Zijderveld R, Roestenberg P, Lyons KM, Goldschmeding R, Klaassen I, Van Noorden CJ, Schlingemann RO. J Histochem Cytochem. 2008 Aug;56(8):785-92. Epub 2008 May 12.
Focal adhesion kinase/Src suppresses early chondrogenesis: central role of CCN2.
Pala D, Kapoor M, Woods A, Kennedy L, Liu S, Chen S, Bursell L, Lyons KM, Carter DE, Beier F, Leask A. J Biol Chem. 2008 Apr 4;283(14):9239-47. Epub 2008 Feb 13.
Connective tissue growth factor/CCN2-null mouse embryonic fibroblasts retain intact transforming growth factor-beta responsiveness.
Mori Y, Hinchcliff M, Wu M, Warner-Blankenship M, M Lyons K, Varga J. Exp Cell Res. 2008 Mar 10;314(5):1094-104. Epub 2007 Dec 23.
Dynamic analysis of the expression of the TGFbeta/SMAD2 pathway and CCN2/CTGF during early steps of tooth development.
Pacheco MS, Reis AH, Aguiar DP, Lyons KM, Abreu JG. Cells Tissues Organs. 2008;187(3):199-210. Epub 2007 Dec 17.
Functional requirement of CCN2 for intramembranous bone formation in embryonic mice.
Kawaki H, Kubota S, Suzuki A, Yamada T, Matsumura T, Mandai T, Yao M, Maeda T, Lyons KM, Takigawa M. Biochem Biophys Res Commun. 2008 Feb 8;366(2):450-6. Epub 2007 Dec 5.
Angiogenesis is not impaired in connective tissue growth factor (CTGF) knock-out mice.
Kuiper EJ, Roestenberg P, Ehlken C, Lambert V, van Treslong-de Groot HB, Lyons KM, Agostini HJ, Rakic JM, Klaassen I, Van Noorden CJ, Goldschmeding R, Schlingemann RO. J Histochem Cytochem. 2007 Nov;55(11):1139-47. Epub 2007 Jul 11.
CCN2 is necessary for the function of mouse embryonic fibroblasts.
Kennedy L, Liu S, Shi-Wen X, Chen Y, Eastwood M, Sabetkar M, Carter DE, Lyons KM, Black CM, Abraham DJ, Leask A. Exp Cell Res. 2007 Mar 10;313(5):952-64. Epub 2006 Dec 23. Erratum in: Exp Cell Res. 2007 Oct 1;313(16):3671. Sabetkar, Mojhgan [added].
BMPs regulate multiple aspects of growth-plate chondrogenesis through opposing actions on FGF pathways.
Yoon BS, Pogue R, Ovchinnikov DA, Yoshii I, Mishina Y, Behringer RR, Lyons KM. Development. 2006 Dec;133(23):4667-78. Epub 2006 Oct 25.
Osteogenic differentiation of mouse adipose-derived adult stromal cells requires retinoic acid and bone morphogenetic protein receptor type IB signaling.
Wan DC, Shi YY, Nacamuli RP, Quarto N, Lyons KM, Longaker MT. Proc Natl Acad Sci U S A. 2006 Aug 15;103(33):12335-40. Epub 2006 Aug 7.
Tracking expression of virally mediated BMP-2 in gene therapy for bone repair.
Gamradt SC, Abe N, Bahamonde ME, Lee YP, Nelson SD, Lyons KM, Lieberman JR.Clin Orthop Relat Res. 2006 Sep;450:238-45.
Cell mixing at a neural crest-mesoderm boundary and deficient ephrin-Eph signaling in the pathogenesis of craniosynostosis.
Merrill AE, Bochukova EG, Brugger SM, Ishii M, Pilz DT, Wall SA, Lyons KM, Wilkie AO, Maxson RE Jr. Hum Mol Genet. 2006 Apr 15;15(8):1319-28. Epub 2006 Mar 15.
CCN2 is necessary for adhesive responses to transforming growth factor-beta1 in embryonic fibroblasts.
Shi-wen X, Stanton LA, Kennedy L, Pala D, Chen Y, Howat SL, Renzoni EA, Carter DE, Bou-Gharios G, Stratton RJ, Pearson JD, Beier F, Lyons KM, Black CM, Abraham DJ, Leask A. J Biol Chem. 2006 Apr 21;281(16):10715-26. Epub 2006 Feb 16.
BMP signaling stimulates cellular differentiation at multiple steps during cartilage development.
Kobayashi T, Lyons KM, McMahon AP, Kronenberg HM. Proc Natl Acad Sci U S A. 2005 Dec 13;102(50):18023-7. Epub 2005 Dec 1.
Fibulin-1 acts as a cofactor for the matrix metalloprotease ADAMTS-1.
Lee NV, Rodriguez-Manzaneque JC, Thai SN, Twal WO, Luque A, Lyons KM, Argraves WS, Iruela-Arispe ML. J Biol Chem. 2005 Oct 14;280(41):34796-804. Epub 2005 Aug 1.
GDF11 controls the timing of progenitor cell competence in developing retina.
Kim J, Wu HH, Lander AD, Lyons KM, Matzuk MM, Calof AL. Science. 2005 Jun 24;308(5730):1927-30.
Nguyen TQ, Roestenberg P, van Nieuwenhoven FA, Bovenschen N, Li Z, Xu L, Oliver N, Aten J, Joles JA, Vial C, Brandan E, Lyons KM, Goldschmeding R. J Am Soc Nephrol. 2008 Jul 16. In press.
A new model for growth factor activation: type II receptors compete with the prodomain for BMP-7.
Sengle G, Ono RN, Lyons KM, Bächinger HP, Sakai LY. J Mol Biol. 2008 Sep 12;381(4):1025-39. Epub 2008 Jul 2.
Cooperative Regulation of Chondrocyte Differentiation by CCN2 and CCN3 Revealed by a Comprehensive Analysis of the CCN Family Proteins in Cartilage.
Kawaki H, Kubota S, Suzuki A, Lazar N, Yamada T, Matsumura T, Ohgawara T, Maeda T, Perbal B, Lyons KM, Takigawa M. J Bone Miner Res. 2008 Jul 2. In press.
CCN2 (Connective Tissue Growth Factor) is essential for extracellular matrix production and integrin signaling in chondrocytes.
Nishida T, Kawaki H, Baxter RM, Deyoung RA, Takigawa M, Lyons KM. J Cell Commun Signal. 2007 Jun;1(1):45-58. Epub 2007 May 16.
The 5' untranslated regions (UTRs) of CCN1, CCN2, and CCN4 exhibit cryptic promoter activity.
Huang BL, Dornbach LM, Lyons KM. J Cell Commun Signal. 2007 Jun;1(1):17-32. Epub 2007 Mar 28.
Connective tissue growth factor is necessary for retinal capillary basal lamina thickening in diabetic mice.
Kuiper EJ, van Zijderveld R, Roestenberg P, Lyons KM, Goldschmeding R, Klaassen I, Van Noorden CJ, Schlingemann RO. J Histochem Cytochem. 2008 Aug;56(8):785-92. Epub 2008 May 12.
Focal adhesion kinase/Src suppresses early chondrogenesis: central role of CCN2.
Pala D, Kapoor M, Woods A, Kennedy L, Liu S, Chen S, Bursell L, Lyons KM, Carter DE, Beier F, Leask A. J Biol Chem. 2008 Apr 4;283(14):9239-47. Epub 2008 Feb 13.
Connective tissue growth factor/CCN2-null mouse embryonic fibroblasts retain intact transforming growth factor-beta responsiveness.
Mori Y, Hinchcliff M, Wu M, Warner-Blankenship M, M Lyons K, Varga J. Exp Cell Res. 2008 Mar 10;314(5):1094-104. Epub 2007 Dec 23.
Dynamic analysis of the expression of the TGFbeta/SMAD2 pathway and CCN2/CTGF during early steps of tooth development.
Pacheco MS, Reis AH, Aguiar DP, Lyons KM, Abreu JG. Cells Tissues Organs. 2008;187(3):199-210. Epub 2007 Dec 17.
Functional requirement of CCN2 for intramembranous bone formation in embryonic mice.
Kawaki H, Kubota S, Suzuki A, Yamada T, Matsumura T, Mandai T, Yao M, Maeda T, Lyons KM, Takigawa M. Biochem Biophys Res Commun. 2008 Feb 8;366(2):450-6. Epub 2007 Dec 5.
Angiogenesis is not impaired in connective tissue growth factor (CTGF) knock-out mice.
Kuiper EJ, Roestenberg P, Ehlken C, Lambert V, van Treslong-de Groot HB, Lyons KM, Agostini HJ, Rakic JM, Klaassen I, Van Noorden CJ, Goldschmeding R, Schlingemann RO. J Histochem Cytochem. 2007 Nov;55(11):1139-47. Epub 2007 Jul 11.
CCN2 is necessary for the function of mouse embryonic fibroblasts.
Kennedy L, Liu S, Shi-Wen X, Chen Y, Eastwood M, Sabetkar M, Carter DE, Lyons KM, Black CM, Abraham DJ, Leask A. Exp Cell Res. 2007 Mar 10;313(5):952-64. Epub 2006 Dec 23. Erratum in: Exp Cell Res. 2007 Oct 1;313(16):3671. Sabetkar, Mojhgan [added].
BMPs regulate multiple aspects of growth-plate chondrogenesis through opposing actions on FGF pathways.
Yoon BS, Pogue R, Ovchinnikov DA, Yoshii I, Mishina Y, Behringer RR, Lyons KM. Development. 2006 Dec;133(23):4667-78. Epub 2006 Oct 25.
Osteogenic differentiation of mouse adipose-derived adult stromal cells requires retinoic acid and bone morphogenetic protein receptor type IB signaling.
Wan DC, Shi YY, Nacamuli RP, Quarto N, Lyons KM, Longaker MT. Proc Natl Acad Sci U S A. 2006 Aug 15;103(33):12335-40. Epub 2006 Aug 7.
Tracking expression of virally mediated BMP-2 in gene therapy for bone repair.
Gamradt SC, Abe N, Bahamonde ME, Lee YP, Nelson SD, Lyons KM, Lieberman JR.Clin Orthop Relat Res. 2006 Sep;450:238-45.
Cell mixing at a neural crest-mesoderm boundary and deficient ephrin-Eph signaling in the pathogenesis of craniosynostosis.
Merrill AE, Bochukova EG, Brugger SM, Ishii M, Pilz DT, Wall SA, Lyons KM, Wilkie AO, Maxson RE Jr. Hum Mol Genet. 2006 Apr 15;15(8):1319-28. Epub 2006 Mar 15.
CCN2 is necessary for adhesive responses to transforming growth factor-beta1 in embryonic fibroblasts.
Shi-wen X, Stanton LA, Kennedy L, Pala D, Chen Y, Howat SL, Renzoni EA, Carter DE, Bou-Gharios G, Stratton RJ, Pearson JD, Beier F, Lyons KM, Black CM, Abraham DJ, Leask A. J Biol Chem. 2006 Apr 21;281(16):10715-26. Epub 2006 Feb 16.
BMP signaling stimulates cellular differentiation at multiple steps during cartilage development.
Kobayashi T, Lyons KM, McMahon AP, Kronenberg HM. Proc Natl Acad Sci U S A. 2005 Dec 13;102(50):18023-7. Epub 2005 Dec 1.
Fibulin-1 acts as a cofactor for the matrix metalloprotease ADAMTS-1.
Lee NV, Rodriguez-Manzaneque JC, Thai SN, Twal WO, Luque A, Lyons KM, Argraves WS, Iruela-Arispe ML. J Biol Chem. 2005 Oct 14;280(41):34796-804. Epub 2005 Aug 1.
GDF11 controls the timing of progenitor cell competence in developing retina.
Kim J, Wu HH, Lander AD, Lyons KM, Matzuk MM, Calof AL. Science. 2005 Jun 24;308(5730):1927-30.
Contact Info
Karen M. Lyons, Ph.D.
Biomedical Sciences/
Orthopaedic Hospital Research Building
Office: Room 410C (310)825-5480
Lab: Room 446 (310) 825-6228
Fax: (310)825-5409
Email: klyons@mednet.ucla.edu