Milde, F., Lauw, S. Koumoutsakos, P., and Iruela-Arispe, M.L.. 2013. The mouse retina in 3D: quantification of vascular growth and remodeling Integrative Biology : [link].

Turlo, K.A., Scapa, J., Bagher, P., Jones, A.W., Feil, R., Korthuis, R.J., Segal, S.S., Iruela-Arispe, M.L.. 2013. Beta1-Integrin is essential for vasoregulation and smooth muscle survival In Vivo Arterioscler Thromb Vasc Biol 33: 2325-2335 [link].

Iruela-Arispe, M.L., Beitel, G.J.. 2013. Tubulogenesis Development 140: 2851-2855 [link].

Goddard, L.M., Ton, A.M., Org, T., Mikkola, H.K., Iruela-Arispe, M.L.. 2013. Selective suppression of endothelial cytokine production by progesterone receptor Vascul. Pharmacol 59: 36-43 [link].

Janzen, D.M., Rosales, M.A., Paik, D.Y., Lee, D.S., Smith, D.A., Witte, O.N., Iruela-Arispe, M.L., Memarzadeh, S.. 2013. Progesterone receptor signaling in the microenvironment of endometrial cancer influences its response to hormonal therapy Cancer Res 73: 4697-4710 [link].

Roodhart, J.M.L., He, H., Daenen, L.G.M., Monvoisin, A., Barber, C., van Amersfoort, M., Hofmann, J.J., Radtke, F., Lane, T.F., Voest, E.E., Iruela-Arispe, M.L.. 2013. Notch1 regulates angio-supportive bone-marrow-derived cells in mice: relevance to chemoresistance Blood 122: 143-153 [link].

Baer, C., Squadrito, M.L., Iruela-Arispe, M.L., De Palma, M.. 2013. Reciprocal interactions between endothelial cells and macrophages in angiogenic vascular niches Exp Cell Res 319: 1626-1634 [link].

Cristofaro, B., Shi, Y., Faria, M., Suchting, S., Leroyer, A.S., Trindade, A., Duarte, A., Zovein, A.C., Iruela-Arispe, M.L., Nih, L.R., Kubis, N., Henrion, D., Loufrani, L., Todiras, M., Schleifenbaum, J., Gollasch, M., Zhuang, Z.W., Simons, M., Eichmann, A., le Noble, F.. 2013. Dll4-Notch signaling determines the formation of native arterial collateral networks and arterial function in mouse ischemia models Development 140: 1720-1729 [link].

Goddard, L.M., Iruela-Arispe, M.L.. 2013. Cellular and molecular regulation of vascular permeability Thromb. Haemost 109: 407-415 [link].

Defalco, T., Saraswathula, A., Briot, A., Iruela-Arispe, M.L., Capel, B.. 2013. Testosterone levels influence mouse fetal leydig cell progenitors through Notch signaling Biol. Reprod 88: 1-12 [link].

Mack, J.J., Youssef, K., Noel, O.D., Lake, M.P., Wu, A., Iruela-Arispe, M.L., Bouchard, L.S.. 2013. Real-time maps of fluid flow field in porous biomaterials Biomaterials 34: 1980-1986 [link].

Domigan, C.K., Iruela-Arispe, M.L.. 2012. Recent advances in vascular development Curr Opin Hematol 19: 176-183 [link].

Howell, M.D., Torres-Collado, A.X., Iruela-Arispe, M.L., Gottschall, P.E.. 2012. Selective decline of synaptic protein levels in the frontal cortex of female mice deficient in the extracellular metalloproteinase ADAMTS1 PLoS One 7: e47226- [link].

Hofmann, J.J., Briot, A., Enciso, J., Zovein, A.C., Ren, S., Zhang, Z.W., Radtke, F., Simons, M., Wang, Y., Iruela-Arispe, M.L.. 2012. Endothelial deletion of murine Jagged1 leads to valve calcification and congenital heart defects associated with Alagille syndrome Development 139: 4449-4460 [link].

He, H., Xu, J., Warren, C.M., Duan, D., Wu, L., Iruela-Arispe, M.L.. 2012. Endothelial cells provide an instructive niche for the differentiation and functional polarization of M2-like macrophages Blood 120: 3152-3162 [link].

Avraham-Davidi, I., Ely, Y., Pham, V.N., Castranova, D., Grunspan, M., Malkinson, G., Gibbs-Bar, L., Mayseless, O., Allmog, G., Lo, B., Warren, C.M., Chen, T.T., Ungos, J., Kidd, K., Shaw, K., Rogachev, I., Wan, W., Murphy, P.M., Farber, S.A., Carmel, L., Shelness, G.S., Iruela-Arispe, M.L., Weinstein, B.M., Yaniv, K.. 2012. ApoB-containing lipoproteins regulate angiogenesis by modulating expression of VEGF receptor-1 Nat. Med 18: 967-973 [link].

Chhabra, A., Lechner, A.J., Ueno, M., Acharya, A., van Handel, B., Wang, Y., Iruela-Arispe, M.L., Tallquist, M.D., Mikkola, H.K.. 2012. Trophoblasts regulate the placental hematopoietic niche through PDGF-B signaling Dev. Cell 13: 651-659 [link].

Hall-Glenn, F., De Young, R.A., Huang, B.L., van Handel, B., Hofmann, J.J., Chen, T.T., Choi, A., Ong, J.R., Benya, P.D., Mikkola, H., Iruela-Arispe, M.L., Lyons, K.M.. 2012. CCN2/Connective tissue growth factor is essential for pericyte adhesion and endothelial basement membrane formation during angiogenesis PLoS One 7: e30562- [link].

Turlo, K.A., Noel, O.D., Vora, R., LaRussa, M., Hall-Glenn, F., Iruela-Arispe, M.L.. 2012. An essential requirement for Beta-1 integrin in the assembly of extracellular matrix proteins within the vascular wall Dev. Biol 365: 23-35 [link].

Cooley,M.A., Fresco, V.M., Dorlon, M.E., Twal, W.O., Lee, N.V., Barth, J.L., Kern, C.B., Iruela-Arispe, M.L., Argraves, W.S.. 2012. Fibulin-1 is required during cardiac ventricular morphogenesis for versican cleavage, suppression of ErbB2 and Erk1/2 activation, and to attenuate trabecular cardiomyocyte proliferation Dev. Dyn 241: 303-314 [link].

Scheppke, L., Murphy, E., Zarpellon, A., Hofmann, J.J., Merkulova, A., Shields, D., Weis, S., Byzova, T., Ruggeri, Z., Iruela-Arispe, M.L., Cheresh, D.. 2012. Notch promotes vascular maturation by inducing integrin-mediated smooth muscle cell adhesion to the endothelial basement membrane Blood 119: 2149-2158 [link].

Youssef, K., Mack, J.J., Iruela-Arispe, M.L., Bouchard, L.S.. 2012. Macro-scale topology optimization for controlling internal shear stress in a porous scaffold bioreactor Biotechnol. Bioeng 109: 1844-1854 [link].

Ziyad, S., Iruela-Arispe, M.L.. 2011. Molecular mechanisms of tumor angiogenesis Genes and Cancer. In Press : 1844-1854 [link].

Iruela-Arispe, M.L.. 2011. LUMENating blood vessels Dev. Cell 20: 412-414 [link].

Anderson, S.M., Shergill, B., Barry, Z.T., Manousiouthakis, E., Chen, T.T., Botvinick, E., Platt, M.O., Iruela-Arispe, M.L., and Segura, T.. 2011. VEGF internalization is not required for VEGFR-2 phosphorylation in bioengineered surfaces with covalently linked VEGF Integrative Biology 3: 887-896 [link].

Corada, M., Nyqvist, D., Orsenigo, F., Caprini, A., Giampietro, C., Taketo, M.M., Iruela-Arispe, M.L., Adams, R.H., Dejana, E.. 2010. The Wnt/beta-catenin pathway modulates vascular remodeling and specification by upregulating DII4/Notch signaling Dev. Cell 18: 938-949 [link].

Hofmann, J.J., Zovein, A.C., Koh, H., Radtke, F., Weinmaster, G., and Iruela-Arispe, M.L.. 2010. Jagged1 in the portal vein mesenchyme regulates intrahepatic bile duct development: insights into Alagille syndrome Development 137: 4061-4072 [link].

Turlo, K.A., Gallaher, S.D., Vora, R., Laski, F.A., Iruela-Arispe, M.L.. 2010. When Cre-mediated recombination in mice does not result in protein loss Genetics (highlighted by Journal) 186: 959-967 [link].

Zovein, A.C., Turlo, K.A., Ponec, R.M., Lynch, M.R., Chen, K.C., Hofmann, J.J., Cox, T.C., Gasson, J.C., Iruela-Arispe, M.L.. 2010. Vascular remodeling of the vitelline artery initiates extra-vascular emergence of hematopoietic clusters Blood (Cover) 116: 3435-3444 [link].

Da Silva, R.G., Tavora, B., Robinson, S.D., Reynolds, L.E., Szekeres, C., Lamar, J., Batista, S., Kotourou, V., Germain, M.A., Reynolds, A.R., Jones, D.T., Watson, A.R., Jones, J.L., Harris, A., Hart, I.R., Iruela-Arispe, M.L., Dipersion, C.M., Kreidberg, J.A., Hodivala-Dilke, K.M.. 2010. Endothelial alpha 3 beta1 integrin represses pathological angiogenesis and sustains endothelial VEGF Am. J. Pathol 177: 1534-1548 [link].

Warren, C.M., and Iruela-Arispe, M.L.. 2010. Signaling circuitry in vascular morphogenesis Curr Opin Hematol 17: 213-218 [link].

Arroyo, A.G., and Iruela-Arispe, M.L.. 2010. Extracellular matrix, inflammation, and the angiogenic response Cardiovasc Res 86: 226-235 [link].

Chen, T.T., Luque, A., Lee, S., Anderson, S.M., Segura, T., Iruela-Arispe, M.L.. 2010. Anchorage of VEGF to the extracellular matrix conveys differential signaling responses to endothelial cells J Cell Biol 188: 595-609 [link].

Zovein, A.C., Luque, A., Turlo, K.A., Hofmann, J.J., Yee, K.M., Becker, M.S., Fassler, R., Mellman, I., Lane, T.F., Iruela-Arispe, M.L.. 2010. Beta1 integrin establishes endothelial cell polarity and arteriolar lumen formation via a Par3-dependent mechanism Dev. Cell 18: 39-51 [link].

Stockman, C., Kerdiles, Y., Nomaksteinsky, M., Weidemann, A., Takeda, N., Doedens, A., Torres-Collado, A.X., Iruela-Arispe, M.L., Nizet, V., Johnson, R.S.. 2010. Loss of myeloid cell-derived vascular endothelial growth factor accelerates fibrosis Proc Natl Acad Sci USA 107: 4329-4334 [link].

Lee, Y.J., Koch, M., Karl, D., Torres-Collado, A.X., Fernando, N.T., Rothrock, C., Kuruppu, D., Ryeom, S., Iruela-Arispe, M.L., Yoon, S.S.. 2010. Variable inhibition of thrombospondin 1 against liver and lung metastases through differential activation of metalloproteinase ADAMTS1 Cancer Res 70: 948-956 [link].

Priceman, S.J., Sung, J.L., Shaposhnik,, Z., Burton, J.B., Torres-Collado, A.X., Moughon, D.L., Johnson, M., Lusis, A.J., Cohen, D.A., Iruela-Arispe, M.L., and Wu, L.. 2010. Targeting distinct tumor-infiltrating myeloid cells by inhibiting CSF-1 receptor: combating tumor evasion of anti-angiogenic of anti-angiogenic therapy Blood 114: 469-477 [link].

Iruela-Arispe, M.L., and Lee, S.. 2010. Mechanisms underlying context-dependent VEGF signaling for distinct biological responses Handbook of Cell Signaling, Second Edition : 1919-1925 [link].

Zovein, A.C., and Iruela-Arispe, M.L.. 2009. Time to cut the cord: placental HSCs grow up Cell Stem Cell 5: 351-352 [link].

Skuli, N., Liu, L., Runge, A., Wang, T., Yuan, L., Patel, S., Iruela-Arispe, M.L., Simon, M.C., Keith, B.. 2009. Endothelial deletion of hypoxia-inducible factor-2alpha(HIF-2alpha) alters vascular function and tumor angiogenesis Blood 114: 469-477 [link].

Anderson, S.M., Chen, T.T., Iruela-Arispe, M.L., Segura, T.. 2009. The phosphorylation of vascular endothelial growth factor receptor-2 (VEGFR-2) by engineered surfaces with electrostatically or covalently immobilized VEGF Biomaterials 30: 4618-4628 [link].

Speck, N.A., Iruela-Arispe, M.L.. 2009. Conditional Cre/LoxP Strategies for the Study of Hematopoietic Stem Cell Formation Blood Cells Mol. Dis 43: 6-11 [link].

Iruela-Arispe, M.Luisa. 2008. Regulation of Thrombospondin1 by Extracellular Proteases Current Drug Targets 9: 863-868 [link].

Zovein, A.C. Hofmann, J.J., Lynch, M., French, W.J., Turlo, K.A., Yang, Y., Becher, M.S., Zanetta, L., Dejana, E., Gasson, J. Tallquist, M.D., and Iruela-Arispe, M.L.. 2008. Fate tracing reveals the endothelial origin of hematopoietic stem cells Cell Stem Cell 3: 625-636 [link].

Suarez, Y., Fernandez-Hernando, C., Yu, J., Gerber, S.A., Harrison, K.D., Pober, J.S. Iruela-Arispe, M.L., Merkernschlager, M., and Sessa, W.C.. 2008. Dicer-dependent endothelial microRNAs are necessary for postnatal angiogenesis PNAS 105: 14082-14087 [link].

Rodriguez-Manzaneque, J.C., Carpizo, D., Plaza-Calonge, M.D., Torres-Collado, A.X., Thai, S.N., Simons, M., Horowitz, A., and Iruela-Arispe, M.L.. 2008. Cleavage of syndecan-4 by ADAMTS1 provokes defects in adhesion Int. J. Biochem. Cell Biol In press: 14082-14087 [link].

Guo, W., Lasky, J.L., Chang, C.J., Mosessian, S., Lewis, X., Xiao, Y., Yeh, J.E., Chen, J. Y., Iruela-Arispe, M.L., Varella-Garcia, M., and Wu, H.. 2008. Multi-genetic events collaboratively contribute to Pten-deficient leukemia stem-cell formation Nature 453: 529-533 [link].

Stankunas, K. Hang, C.T., Tsun, Z.Y. Chen, H., Lee, N.V., Wu, J.I., Shang, C., Bayle, J.H., Shou, W., Iruela-Arispe, M.L., and Chang, C.P.. 2008. Endocardial Brg1 represses ADAMTS1 to maintain the microenvironment for myocardial morphogenesis Dev. Cell 14: 298-311 [link].

Misra, S., Lee, N. Fu, A.A., Raghavakaimal, S., Mandrekar, J., Bjarnason, H., McKusick, M.A., Iruela-Arispe, L., Mukhopadhyay, D.. 2008. Increased expression of a disintegrin and metalloproteinase thrombospondin 1 in thrombosed hemodialysis grafts J. Vasc. Interv. Radiol 19: 111-119 [link].

Iruela-Arispe, M.L.. 2008. Endothelial Cell Activation Angiogenesis: An Integrative Approach from Science to Medicine : 35-43 [link].

Lundkvist, A., Lee, S., Iruela-Arispe, L., Betsholtz, C., Gerhardt, H.. 2007. Growth factor gradients in vascular patterning Novartis Found. Symp 283: 194-201 [link].

Lee, S. and Iruela-Arispe, M.L.. 2007. The Extracellular Matrix and VEGF Processing Anti-Angiogenesis, 2nd edition : 194-201 [link].

Hofmann, J.J. and Iruela-Arispe M.L.. 2007. Notch expression patterns in the retina: An eye on receptor-ligand distribution during angiogenesis Gene Expr Patterns 7: 461-470 [link].

Lee, M., Chen, T.T., Iruela-Arispe, M.L., Wu, B.M., Dunn, J.C.. 2007. Modulation of protein delivery from modular polymer scaffolds Biomaterials 28: 1862-1870 [link].

Hellstrom, M., Phng, L.K., Hofmann, J.J., Wallgard, E., Coultas, L., Lindblom, P., Alva, J., Nilsson, A.K., Karlsson, L., Gaiano, N., Yoon, K., Rossant, J., Iruela-Arispe, M.L., Kalen, M., Gerhardt, H., Betsholtz, C.. 2007. D114/Notch1 regulates formation of tip cells during angiogenesis Nature 445: 776-780 [link].

Hofmann, J.J., Iruela-Arispe, M.L.. 2007. Notch signaling in blood vessels: who is talking to whom about what? Circulation Res 100: 1556-1568 [link].

Lee, S., Chen, T.T., Barber, C.L., Jordan, M.C., Murdock, J., Desai, S., Ferrara, N., Nagy, A., Roos, K.P. and Iruela-Arispe, M.L.. 2007. Autocrine VEGF Signaling Is Required for Vascular Homeostasis Cell 130: 691-703 [link].

Lee, N.V. and Iruela-Arispe, M.L.. 2006. Thrombospondins and Angiogenesis Tumor Angiogenesis: Mechanisms and Cancer Therapy : 233-245 [link].

Zovein, A.C. and Iruela-Arispe, M.L.. 2006. My O'Myeloid, a tale of two lineages PNAS 29103: 12959-12960 [link].

Iruela-Arispe, M.L.. 2006. When it comes to lymphatics, it is all a question of time Am J. Pathol 169: 347-350 [link].

Barber, C.L., and Iruela-Arispe, M.L.. 2006. The ever-Elusive Endothelial Progenitor Cell: Identities, Functions and Clinical Implications Pediatr Res 59: 26-32 [link].

Alva, J.A., Zovein, A.C., Monvoisin, A., Murphy, T., Salazar, A., Harvey, N.L., Carmeliet, P. and Iruela-Arispe, M.L.. 2006. VE-Cadherin-Cre-recombinase transgenic mouse: A tool for lineage analysis and gene deletion in endothelial cells Dev Dyn 235: 759-767 [link].

Yang, L.V., Radu, C.G., Roy, M., Lee, S., McLaughlin, J., Teitell, M.A., Iruela-Arispe M.L. and Witte, O.N.. 2006. Vascular abnormalities in mice deficient for the G protein-coupled receptor GPR4 that functions as a pH sensor Mol Cell Biol 27: 1334-1347 [link].

Kern, C.B., Twal, W.O., Mjaatvedt, C.H., Fairey, S.E., Toole, B.P., Iruela-Arispe, M.L., Argraves, W.S. 2006. Proteolytic cleavage of versican during cardiac cushion morphogenesis Dev Dyn 235: 2238-2247 [link].

Torres-Collado, A.X., Kisiel, W., Iruela-Arispe, M.L., Rodriguez-Manzaneque, J.C. 2006. ADAMTS1 interacts with, cleaves and modifies the extracellular location of the matrix inhibitor tissue factor pathway inhibitor-2 (TFPI-2) J Biol Chem 281: 17827-17837 [link].

Monvoisin, A., Alva, J.A., Hofmann, J.J., Zovein, A.C., Lane, T.F., and Iruela-Arispe, M.L. 2006. VE-cadherin-CreER(T2) transgenic mice: A model for inducible recombination in the endothelium Dev. Dyn 235: 3413-3422 [link].

Lee, N.V., Sato, M., Annis, D.S., Loo, J.A., Wu, L., Mosher, D.F. and Iruela-Arispe, M.L. 2006. ADAMTS1 mediates the release of anti-angiogenic polypeptides from TSP1 and TSP2 The EMBO J 25: 5270-5283 [link].

Hashimoto-Partyka, M., Lydon, J., and Iruela-Arispe, M.L. 2006. Generation of a mouse for conditional excision of progesterone receptor (PRCE) Genesis 44: 391-395 [link].

Iruela-Arispe, M.L.. 2005. Vascular Development and Angiogenesis Encyclopedia of Molecular Cell Biology and Molecular Medicine : 201-232 [link].

Lee, N.V., Rodriguez-Manzaneque, J.C., Thai, S.N., Twal, W.O., Luque, A., Lyons, K.M., Argraves, W.S., Iruela-Arispe, M.L. 2005. Fibulin-1 acts as a cofactor for the matrix metalloprotease ADAMTS-1 J Biol Chem 280: 34796-34804 [link].

Cho, H.M., Rosenblatt, J.D., Kang, Y.S., Iruela-Arispe, M.L., Morrison, S.L., Penichet, M.L., Kwon, Y.G., Kim, T.W., Webster, K.A., Nechustan, H. and Shin, S.U.. 2005. Enhanced inhibition of murine tumor and human breast tumor xenografts using targeted delivery of an antibody-endostatin fusion protein Mol Cancer Ther 4: 956-967 [link].

Lee, S., Jilani, S.M. Nikolova, G.V., Carpizo, D., and Iruela-Arispe, M.L. 2005. Processing of VEGF-A by matrix metalloproteinases regulates bioavailability and vascular patterning in tumors J Cell Biol 169: 681-691 [link].

Krampert, M., Kuenzle, S., Thai, S.N., Lee, N., Iruela-Arispe, M.L., Werner, S. 2005. ADAMTS1 proteinase is upregulated in wounded skin and regulates migration of fibroblasts and endothelial cells J Biol Chem 280: 23844-23852 [link].

Thomas-Tikkonenko, A. and Iruela-Arispe, M.L.. 2004. Whence Thrombospondin? Cancer Biology and Therapy 3: 60-61 [link].

Alva, J.A. and Iruela-Arispe, M.L.. 2004. Notch Signaling in Vascular Morphogenesis Current Opinion in Hematology 11: 278-293 [link].

Iruela-Arispe, M.L., Luque, A. and Lee, N.. 2004. Thrombospondin modules in Angiogenesis Int. Journal of Biochemistry and Cell Biol 36: 1070-1078 [link].

Iruela-Arispe, M.L.. 2004. Angiogenesis: novel and basic science insights and human therapy. Keystone Symposium - IDrugs 7: 111-113 [link].

Fiala, M., Murphy, T., MacDougall, J., Yang, W., Luque, A., Iruela-Arispe, L., Cashman, J., Buga, G., Byrns, R.E., Barbaro, G., Arthos, J.. 2004. HAART drugs induce mitochondrial damage and intercellular gaps and gp120 causes apoptosis Cardiovasc Toxicol 4: 327-337 [link].

Calzada, M.J., Zhou, L., Sipes, J.M., Zhang, J., Krutzsch, H.C., Iruela-Arispe M.L., Annis, D.S., Mosher, D.F., Roberts, D.D.. 2004. Alpha4 Beta1 Integrin Mediates Selective Endothelial Cell Responses to Thrombospondins 1 and 2 In Vitro and Modulates Angiogenesis In Vivo Circ Res 94: 462-470 [link].

Ellwood-Yen K, Graeber TG, Wongvipat J, Iruela-Arispe ML, Zhang J, Matusik R, Thomas GV, Sawyers CL. 2003. Myc-driven murine prostate cancer shares molecular features with human prostate tumors Cancer Cell 4: 223-238 [link].

Iruela-Arispe, M.L., Carpizo, D., Luque, A.. 2003. ADAMTS1: a matrix metalloprotease with angioinhibitory properties Ann N Y Acad Sci 995: 183-190 [link].

Jilani SM, Murphy TJ, Thai SN, Eichmann A, Alva JA, Iruela-Arispe ML. 2003. Selective binding of lectins to embryonic chicken vasculature J Histochem Cytochem : 597-604 [link].

Park H.J., Kong D., Iruela-Arispe M.L., Begley U, Tang D, Galper J.B.. 2002. 3-hydroxy-3methylglutaryl coenzyme A reductase inhibitors interfere with angiogenesis by inhibiting the geranylgeranylation of RhoA Circ Res 91: 143-150 [link].

Gaspar, J., Thai, S., Voland, C., Dube, A., Libermann, T.A., Iruela-Arispe, M.L. and Oettgen, P.. 2002. Opposing functions of the Ets factors NERF and ELF-1 in the regulation of the Tie genes during chicken blood vessel development Art. Throm. and Vasc. Biol 22: 1106-1112 [link].

Adams, J.Y., Johnson, M., Sato, M., Berger, F., Gambhir, S.S., Carey, M., Iruela-Arispe, M.L. and Lily, Wu. 2002. Visualization of advanced human prostate cancer lesions in living mice by a targeted gene transfer vector and optical imaging Nature Med 8: 891-897 [link].

Thai, S.N.M. and Iruela-Arispe, M.L.. 2002. Expression of ADAMTS1 during murine development Mechanisms of Development 115: 181-185 [link].

Rogriguez-Manzaneque, J.C., Westling, J., Thai, S.N., Luque, A., Knauper, V., Murphy, G., Sandy, J.D., and Iruela-Arispe, M.L.. 2002. ADAMTS1 cleaves aggrecan at multiple sites and is differentially inhibited by metalloproteinase inhibitors Biochem. and Biophys. Res. Comm 293: 501-508 [link].

Iruela-Arispe, M.L. and Graubert, M.D.. 2002. Vascular endothelial growth factor, transforming growth factor alpha and estrogen receptors: possible cross-talks and interactions Am. J. Pathol 160: 381-383 [link].

Murayama, Y., Vinuela, F., Tateshima, S., Gonzalez, N.R., Song, J.K., Mahdavieh, H., Iruela-Arispe, M.L.. 2002. Cellular responses of bioabsorbable polymeric material and Guglielmi detachable coil in experimental aneurysms Stroke 33: 1120-1128 [link].

Rodriguez-Manzaneque, J.C., Lane, T.F., Ortega, M.A., Hynes, R.O., Lawler, J., and Iruela-Arispe, M.L.. 2001. Thrombospondin-1 suppresses spontaneous tumor growth and inhibits activation of matrix metalloproteinase-9 and mobilization of vascular endothelial growth factor PNAS 98: 12485-12490 [link].

Villa, N., Walker, L., Lindsell, C.E., Gasson, J., Iruela-Arispe, M.L. and Weinmaster, G.. 2001. Vascular expression of Notch pathway receptors and ligands is restricted to arterial vessels Mechanisms of Development 108: 161-164 [link].

Augustin, H.G., Iruela-Arispe, M.L., Rogers, P., and Smith, S.. 2001. Vascular Morphogenesis in the Female Reproductive System Springer-Birkhaeuser, New York : 161-164 [link].

Saaristo, A., Karkkainen, M.J., Alitalo, K., Montesano, R., Iruela-Arispe, M.L., Pepper, M.S.. 2001. Growth factor regulation of physiological angiogenesis in the mammary gland Chapter in: Vascular Morphogenesis in the Female Reproductive System : 25-40 [link].

Iruela-Arispe, M.L., Ortega, M.A., Oikemus, S. and Pepper, M.S.. 2001. Vascular morphogenesis in the mammary gland - introduction and overview Vascular Morphogenesis in the Female Reproductive System : 3-24 [link].

Sandy, J.D., Westling, J., Kenagy, R.D., Iruela-Arispe, M.L., Verscharen, C., Rodriguez-Manzaneque, J.C., Zimmerman, D., Lemire, J.M., Fischer, J.W., Wight, T.N and Clowes, A.W.. 2001. Versican V1 proteolysis in human aorta in vivo occurs at the Glu441-Ala442 bond, a site which is cleaved by recombinant ADAMTS-1 and ADAMTS-4 J. Biol. Chem 276: 13372-13378 [link].

Dube, A., Thai, S., Gaspar, J., Rudders, S., Libermann, T.A., Iruela-Arispe, M.L., and Oettgen, P.. 2001. ELF-1 is a transcriptional regulator of the Tie-2 gene during vascular development Circ. Res 88: 237-244 [link].

Graubert, M.D., Ortega, M.A., Kessel, B., Mortola, J.F. and Iruela-Arispe, M.L.. 2001. Vascular repair after menstruation involves regulation of vascular endothelial growth factor-receptor phosphorylation by sFLT-1 Am. J. Pathol 158: 1399-1410 [link].

Carpizo, D. and Iruela-Arispe, M.L.. 2000. Endogenous regulators of angiogenesis - Emphasis on proteins with thrombospondin - type I motifs Cancer and Metastasis Reviews 19: 159-165 [link].

Pal, S., Iruela-Arispe, M.L., Harvey, V.S., Zeng, H., Nagy, J.A., Dvorak, H.F. and Mukhopadhyay, D.. 2000. Retinoic acid selectively inhibits the vascular permeabilizing effect of VPF/VEGF, an early step in the angiogenic cascade Microvasc. Res 60: 112-120 [link].

Rodriguez-Manzaneque, J.C., Milchanowski, A.B., Dufour, E.K., Leduc, R., and Iruela-Arispe, M.L.. 2000. Characterization of Meth-1/Adamts-1 processing reveals two distinct active forms J. Biol. Chem 275: 33471-33479 [link].

Streit, M., Valesco, P., Riccardi, L., Spencer, L., Brown, L.F., Janes, L., Lange-Asschenfeldt, B. ,Yano, K., Hawighorst, T., Iruela-Arispe, M.L., and Detmar, M.. 2000. Thrombospondin-1 suppresses wound healing and granulation tissue formation in the skin of transgenic mice The EMBO Journal 19: 3272-3282 [link].

Pepper, M.S., Baetens, D., Mandroita, S.J., Di Sanza, C., Oikemus, S., Lane, T.F., Soriano, J.V., Orci, L., Montesano, R., Iruela-Arispe, M.L.. 2000. Regulation of VEGF and VEGF receptor expression in rodent mammary gland during pregnancy, lactation and involution Dev. Dynamics 218: 507-524 [link].

Lee S.W., Reimer, C.L., Fang, L., Iruela-Arispe, M.L. and Aaronson, S.A.. 2000. Overexpression of kinase-associated phosphatase (KAP) in Breast and Prostate Cancer Inhibition of the transformed phenotype by antisense KAP Expression Molec. & Cell. Biol 20: 1723-1732 [link].

Chandrasekaran, L., He, Z.C., Al-Barazi, H., Krutzch, H.C., Iruela-Arispe, M.L., and Roberts, D.D.. 2000. Cell contact-dependent activation of a 3b1 integrin modulates endothelial cell responses to thrombospondin-1 Mol. Biol. Cell 11: 2885-2900 [link].

Rodriguez-Manzaneque, J.C., Graubert, M., and Iruela-Arispe, M.L.. 2000. Endothelial cell dysfunction following prolonged activation of progesterone receptor Human Reproduction 15: 39-47 [link].

Iruela-Arispe, M.L., Ortega, M.A., and Vazquez, F.. 1999. Antiangiogenic Function of Thrombospondin-1 Angiogenesis in Health and Disease: Basic Mechanisms and Clinical Applications : 349-357 [link].

Iruela-Arispe, M.L., Vazquez, F., and Ortega, M.A.. 1999. Anti-angiogenic domains shared by thrombospondins and metallospondins, a new family of angiogenic inhibitors Ann. N.Y. Acad. Sci 886: 58-66 [link].

Iruela-Arispe, M.L., Lombardo, M., Krutzsch, H.C., Lawler, J., and Roberts, D.D.. 1999. Inhibition of angiogenesis by thrombospondin-1 is mediated by two independent regions within the type1 repeats Circulation 100: 1423-1431 [link].

Wu. H., Lee, S.H., Jing Gao, Xin Liu, and Iruela-Arispe, M.L.. 1999. Inactivation of erythropoetin leads to defects in cardiac morphogenesis Development 126: 3597-3605 [link].

Vazquez, F., Hasting, G., Ortega, M.A., Lane, T.F., Oikemus, S., Lombardo, M., and Iruela-Arispe, M.L.. 1999. METH1 a human ortholog of ADAMTS, and METH2 are members of a new family of proteins with angio-inhibitory activity J. Bio. Chem 274: 23349-23357 [link].

Zhai, Y., Yu, L., Iruela- Arispe, L., Huang, W.Q., Wang, Z., Hayes, A.J., Lu, J., Jaing, G., Rojas, L., Lippman, M.E., Ni, J., Yu, G.L., and Li, L.Y.. 1999. Inhibition of angiogenesis and breast cancer xenograft tumor by VEGI, a novel cytokine of the TNF superfamily Int. J. Cancer 82: 131-136 [link].

Brown, L.F., Guidi, A.J., Schnitt, S.J., Van De Water, L., Iruela- Arispe, M.L., Yeu, T.K., Tognassi, K., Dvorak, H.F.. 1999. Vascular stroma formation in carcinoma in situ, invasive carcinoma, and metastatic carcinoma of the breast Clin. Cancer Res 5: 1041-1056 [link].

Iruela-Arispe, M.L., Rodriguez- Manzaneque, and Abu-Jawdeh, G.. 1999. Endometrical endothelial cells express estrogen and progesterone receptors and exhibit a tissue specific response to antiogenic growth factors Microcirculation 6: 127-140 [link].

Dhanabal, M., Ramchandran, R., Volk, R., Stillman, I.E., Lombardo, M., Iruela-Arispe, M.L., Simons, M., and Sukhatme, V.P.. 1999. Endostatin: yeast production, mutants, and anti-tumor effect in renal cell carcinoma Cancer Res 59: 189-197 [link].

Vazquez, F., Rodriguez-Manzaneque, J.C., Lydon, J.P., Edwards, D.P., O'Malley B.W., and Iruela-Arispe, M.L.. 1999. Progesterone regulates proliferation of endothelial cells J. Biol. Chem 274: 2185-2192 [link].

Lee, S.H.,Hungerford, J.E., Little, C.D. and Iruela-Arispe, M.L.. 1997. Proliferation and differentiation of smooth muscle cell precursors occurs simultaneously during the development of the vessel wall Dev. Dyn 209: 342-352 [link].

Iruela-Arispe, M.L. and Dvorak, H.F.. 1997. Angiogenesis: A dynamic balance of stimulator and inhibitors Thromb. Haem 78: 672-677 [link].

Iruela-Arispe, M.L.. 1997. Normal placentation: A tale that requires an epithelial-to-endothelial conversion J. Clin.Invest 99: 2057-2058 [link].

Brown, L.F., Demar, M., Tognazzi, K., Abu-Jawdeh., G. and Iruela-Arispe, M.L.. 1997. Uterine smooth muscle cells express functional receptors (flt-1 and KDR) for vascular permeability factor (vascular endothelial growth factor) Lab. Invest 76: 245-255 [link].

Luther, T., Flossel, C., Mackman, N., Bierhaus, A., Kasper, M., Albrecht, S., Sage, E.H., Iruela-Arispe, L., Grossmann, H., Ströhlein, A., Zhang, Y., Nawroth, P.P., Carmeliet, P., Loskutoff, D.J., and Mueller, M.. 1996. Tissue factor expression during human and mouse development Am. J. Pathol 149: 101-113 [link].

Iruela-Arispe, M.L., Vernon, R.B., Wu, H., Jaenish, R., and Sage, E.H.. 1996. Type I collagen-deficient mov 13 mice do not retain SPARC in the extracellular matrix: Implications for fibroblast function Dev. Dyn 207: 171-183 [link].

Gariano, R.F., Iruela-Arispe M.L., Sage, E. H., and Hendrickson, A.E.. 1996. Immunohistochemical characterization of developing and mature primate retinal blood vessels Invest. Ophthalmol. & Visual Science 37: 93-103 [link].

Iruela-Arispe, M.L., Porter, P., Borstein, P., and Sage E.H.. 1996. Thrombospondin-1, an inhibitor of angiogenesis, is regulated by progesterone in human endometrium J. Clin. Invest 97: 403-412 [link].

Iruela-Arispe, L., Gordon, K., Hugo, C., Duijvestijn, A. M. Claffey, K.P., Reilly, M., Couser, W. G., Alpers, C.E. and Johnson, R.J.. 1995. Participation of glomerular endotheial cells in the capillary repair of glomerulonephritis Am. J. Pathol 147: 1715-1728 [link].

Reed, M.J., Iruela-Arispe, M.L., O' Brein, E.R., Truong, T., LaBell, T., Borstein, P., and Sage E.H.. 1995. Expression of thrombospondins by endotheial cells: injury is correlated with TSP1 Am. J. Pathol 147: 1068-1080 [link].

Seiffert, D., Iruela-Arispe, M.L., Sage, E.H., and Loskutoff, D.J.. 1995. Distribution of vitronectin mRNA during murine development Dev. Dyn 203: 71-79 [link].

Vernon, R.B., Lara, S.L., Drake, C.J., Iruela-Arispe, M.L., Angello J.C., Little, C.D., Wight, T.N. and Sage, E.H.. 1995. Organized Type I collagen influences endothelial patterns during "spontaneous angiogenesis in vitro": planar cultures as models of vascular development Cell Dev. Biol 31: 120-131 [link].

Iruela-Arispe, M.L., Lane, T.F., Redmond, D., Reilly, M., Bolender, R., and Kavanaugh, T.J. and Sage E.H.. 1995. Expression of SPARC during the development of the chorioallantoic membrane: protein degradation produces angiogenic peptides Mol. Biol. Cell 6: 327-343 [link].

Gariano, R.F., Iruela-Arispe, M.L. and Hendrickson, A.E.. 1994. Vascular Development in the primate retina: Comparison of laminar plexus formation in monkey and human Invest. Ophtal. Vis. Sci 35: 3442-3455 [link].

Lane, T.F., Iruela-Arispe, M.L., Johnson, R.S. and Sage, E.H.. 1994. SPARC is a source of copper-binding peptides that stimulate angiogenesis J. Cell Biol 125: 929-943 [link].

Battegay, E. J., Rupp, J., Iruela-Arispe, M.L., Sage, E.H., and Pech, M.. 1994. PDGF-BB modulates endothelial proliferation and angiogenesis in vitro via PDGFB-receptors, J. Cell Biol 125: 917-928 [link].

Iruela-Arispe, M.L.,Liska, D.A., Sage, E.H. and Borenstein, P.. 1994. Differential of Expression of Thrombospondin 1, 2, an 3 during Murine Development Dev. Dyn 197: 40-56 [link].

Bassuk, J.A., Iruela-Arispe, M.L., Lane, T.F., Benson, J. M., Berg, R.A., and Sage, E.H.. 1993. Molecular analysis of chicken embryo SPARC Europ. J Biochem 218: 117-127 [link].

Iruela-Arispe, M.L., and Sage, E.H.. 1993. Endothelial Cells Exhibiting Angiogenesis In vitro Proliferate in Response to TGF-B1 J. Cell. Biochem 52: 414-430 [link].

Floege, J., Johnson, R.J., Gordon, K., Yoshimura, A., Campell, C., Iruela-Arispe, M.L., Alpers, C.E., Couser, W.G.. 1992. Altered Glomerular Extracellular Matrix Synthesis in Experimental Membranous Nephropathy Kidney Int 42: 573-585 [link].

Javelainen, H.T., Iruela-Arispe, M.L., Kinsella, M.G. Sandell, L.J., Sage, E.H., and Wight, T.N.. 1992. Expression of decorin by sprouting bovine aortic endothelial cells exhibiting angiogenesis in Vitro Exp. Cell Res 203: 395-401 [link].

Sage, E.H., Lane, T.F., Iruela-Arispe, M.L. and Funk, S.E.. 1992. A Protein that Modulates Cell Cycle and Cell-matrix Interactions Proc. Forth Int'l Conf. Chem. Biol. Mineraliz. Tiss : 235-242 [link].

Lane, T., Iruela-Arispe, M.L. and Sage, E.H.. 1992. Regulation of Gene Expression by SPARC during Angiogenesis in vitro: Changes in Fibronectin, Thrombospondin- 1, and Plasminogen Activator Inhibitor- 1 J. Bio. Chem 267: 16736-16745 [link].

Vernon R.B., Angello, J.C., Iruela-Arispe, M.L., Lane, T.F., and Sage E.H.. 1992. Reorganization of Basement Membrane Matrices by Cellular Traction Promotes the Formation of Cellular Networks in vitro Lab. Invest 66: 536-547 [link].

Iruela-Arispe, M.L., Chun, L., and Sage, E. H.. 1992. Structure and Biology of Type 8 Collagen Trends Glycosci. Glycotechnol 4: 188-199 [link].

Raines, E.W., Lane, T., Iruela-Arispe, M.L.,Ross, R., and Sage, E.H.. 1992. The Extracellular Glycoprotein SPARC Interacts with Platelet-derived Growth Factor (PDGF)-AB and BB and Inhibits Binding of PDGF to its Receptor Proc. Natl.Acad. Sci 89: 1281-1285 [link].

Iruela-Arispe, M.L., Diglio, C.A. and Sage, E.H.. 1991. Modulation of Extracellular Matrix Proteins by Endothelial Cells undergoing Angiogenesis in vitro Arterioscler. Thromb 11: 805-815 [link].

Fouser, L., Iruela-Arispe, M.L., Borstein, P., and Sage, E.H.. 1991. Transcriptional Activity of the alpha 1(I)-Collagen Promoter in Endothelial Cells is Correlated with the Formation of Capillary-like Structures by Endothelial Cells in Vitro J. Biol. Chem 266: 18345-18351 [link].

Iruela-Arispe, M.L., Bornstein, P., and Sage, H.. 1991. Thrombospondin Exerts an Antiangiogenic Effect on Tube Formation by Endothelial Cells in vitro Proc. Natl. Acad. Sci 88: 5026-5030 [link].

Iruela-Arispe, M.L., and Sage, H.. 1991. Expression of Type 8 Collagen during Morphogenesis of the Chicken and Mouse Heart Dev. Biol 144: 107-118 [link].

Paulus, W., Sage, H., Liszka, U., Iruela-Arispe, M.L. and Jellinger, K.. 1991. Increased levels of type VIII collagen in human brain tumours compared to normal brain tissue and non-neoplastic cerebral disorders Brit. J. Cancer 63: 367-371 [link].

Iruela-Arispe, M.L. Hasselaar, P., Sage, H.. 1990. Differential Expression of Extracellular Proteins is correlated with Angiogenesis in vitro Lab. Invest 64: 174-186 [link].

Sage, H. and Iruela-Arispe, M.L.. 1990. Type 8 Collagen in Murine Development. Association with Capillary Formation in vitro Structure, Molecular Biology and Pathology of Collagen 580: 17-31 [link].

Sage, H., Vernon, R.D., Decker, J., Funk, S., and Iruela-Arispe, M.L.. 1989. Distribution of the Calcium-binding Protein SPARC in Tissues of Embryonic and Adult Mice J. Histochem. Cytochem 37: 819-829 [link].

Chow, M., Boyd, C.D., Iruela-Arispe, M.L., Wrenn, D.S., Mecham, R., and Sage, H.. 1989. Characterization of Elastin Protein and mRNA from Salmonid Fish (Oncorhynchus kisutch) Comp. Biochem. Physiol 93: 835-845 [link].

Cotta-Pereira, G. and Iruela-Arispe, M.L.. 1989. Extracellular matrix: Functional significance of oxytalan, elaunin and elastic fibers Cells and Tissues: A ThreeDimensional Approach by Modern Techniques in Microscopy : 61-67 [link].

Cotta-Pereira, G. and Iruela-Arispe, M.L.. 1988. Extracurricular Matrix: Functional Significance of Oxytalan, Elaunin and Elastic Fibers Quaderni di Anatomia Practica : 73- [link].