Honors Collegium 70A
Genetic Engineering in Medicine, Law, & Agriculture
Winter 2014

Professor Bob Goldberg


Course Documents

Course Info:
  Units: 5.0
  Lectures: Tues & Thurs : 3:30 - 6:00 PM
  Location: La Kretz 120
  Discussions: Wed : 1:00 - 3:00 PM Mike Lyons (La Kretz 100)
Wed : 3:00 - 5:00 PM Reece Fenning (La Kretz 100)
Wed : 5:00 - 7:00 PM William Barshop (La Kretz 100)

  Office Hours: Mon: 2:00PM - 4:00PM Reece Fenning (Hershey Hall 318)
Tues: 12:30PM - 2:30PM William Barshop (Hershey Hall 318)
Thur: 9:00AM - 11:00AM Mike Lyons (Hershey Hall 318)
Fri: 11:30AM - 1:30PM Dr. Bob Goldberg (Terasaki Life Sci 4121)
Class Video
Class Syllabus

Class Handouts and Powerpoint Presentation

Week 1


01/07/14 - Lecture One Handout (pdf): The Age of DNA: What is Genetic Engineering? (Part One)
01/9/14 - Film:  Gene Egineers: Playing God


Week 2


01/14/14 - Lecture Two Handout (pdf): The Age of DNA: What is Genetic Engineering? (Part Two)
01/16/14 - Film:  Race for the Double Helix


Week 3


01/21/14 - Lecture Three Handout (pdf): What Are Genes & How Do They Work: (Part One)
01/23/14 - Guest Speaker Handout (pdf):
                  Engineering Crops For the Developing World by Dr. Prakash
                  GMO and Public Policy by Dr. McHughen


Week 4


01/28/14 - Lecture Four Handout (pdf): What Are Genes & How Do They Work: (Part Two)
01/30/14 - Guest Speaker Handout (pdf): Frankenstein's Cat - What The Future Holds For Engineering Life by Emily Anthes


Week 5


02/04/14 - Film:  Conviction
02/06/14 - Lecture Five Handout (pdf): How Are Genes Cloned & Engineered: The Hemophilia Story


Week 6


02/11/14 - All-Class Midterm Oral Exam
02/13/14 - Lecture Six Handout (pdf): Twenty-First Century Genetic Engineering Applications


Week 7


02/18/14 - Lecture Seven Handout (pdf): Your Personal Genome & Tracing Your Ancenstry
02/20/14 - Guest Speaker Handout (pdf): Stem Cell Biology and Ethics by Dr. Pei Yun Lee


Week 8


02/25/14 - Lecture Eight Handout (pdf) by Dr. John Harada: Human Genetic Engineering & Gene Therapy
02/27/14 - Guest Speaker Handout (pdf): In Vitro Fertilization & Genetic Testing by Dr. Michele Evans


Week 9


03/04/14 - Lecture Nine Handout (pdf): Science & the Constitution: Regulating Science & GMO
03/06/14 - Film:  Extraordinary Measures

Week 10


03/11/14 - Lecture Ten Handout (pdf): Science and the Constitution: Who Owns Your Genes?
03/13/14 - Final All-Class Oral Exam

Guest Speakers (Click on the name for information about the speaker)
  Dr. Channapatna Prakash, Ph.D.
Professor in Plant Molecular Genetics, Tuskegee University
Title: Engineering Crops for the Developing World

  Dr. Alan McHughen, Ph.D.
CE Plant Biotechnologist, Department of Plant Sciences, UC Riverside
Title: GMO and Public Policy

  Dr. PeiYun Lee, Ph.D.
UCLA Department of Molecular, Cell, and Developmental Biology
Title: Stem Cells Biology and Ethics
  Dr. Michele Evans, M.D., FACOG
Reproductive Specialist, Pacific Fertility Center Los Angeles
Title: In Vitro Fertilization & Genetic Testing
  Ms. Emily Anthes
Science Journalist and Author
Frankenstein's Cat - What The Future Holds for Engineering Life
Articles For Discussion
Discussion One: Genetic Engineering Then & Now
(click here to download the articles)
1. Stanley N. Cohen, The Manipulation of Genes, Scientific American, June, 1992, 233(1), 24-33.
2. Stanley N. Cohen, DNA Cloning: A personal view after 40 years, PNAS, September 23, 2013, 110(39), 15521-15529.
3. Clifford Grobstein, The Recombinant DNA Debate, Scientific American, July, 1977, 237(1), 22-33.
Discussion Two: Scientific Origins of Genetic Engineering & Biotechnology
(click here to download the articles)
1. Walter Gilbert, DNA Sequencing and Gene Structure, Nobel Lecture Harvard University, December 8, 1980, 408-426.
2. Walter Gilbert and Lydia Villa-Komaroff, Useful Proteins From Recombinant Bacteria, Scientific American, April, 1980, 242(4), 74-94.
Discussion Three: Crop Genetic Engineering
(click here to download the articles)
1. Charles S. Gasser and Robert T. Fraley, Transgenic Crops, Scientific American, June, 1992, 266(6), 62-69.
2. David H. Freedman, Are Engineered Foods Evil?, Scientific American, September, 2013, 80-85.
3. Mark Lynas, Lecture to Oxford Farming Conference, www.marklynas.org/2013/01/lecture-to-oxford-farming-conference-3-january-2013/.

Discussion Four: How to Mark Your Genes
(click here to download the articles)
1. Ray White & Jean-Marc Lalouel, Chromosome Mapping with DNA Markers, Scientific American, February 1988, 258(2), 40-48.
2. Mark A. Rothstein, Keeping Your Genes Private, Scientific American, September 2008, 299(3), 64-69.
3. Melissa Healy, DNA Sequencer raises doctors' hopes for personalized medicine, LA Times, January 3, 2014.
4. Bonnie Rochman, The DNA Dilemma: A Test That Could Change Your Life, Time Magzine, December 24, 2012.
5. Andrew Pollack, DNA Blueprint for Fetus Built Using Tests of Parents, New York Time, June 6, 2012.
Discussion Five: DNA and the Law
(click here to download the articles)
1. Peter J. Neufeld & Neville Coleman, When Science Takes the Witness Stand, Scientific American, May, 1990, 262(5), 46-53.
2. Caitlin Smith, Stephen Strauss, & Laura DeFrancesco, DNA Goes to Court, Nature Biotechnology, November, 2012, 30(11), 1047-1052.
3. Max M. Houck, CSI: Reality, Scientific American, July, 2006, 295(1), 85-89.
Discussion Six: Animal Genetic Engineering
(click here to download the articles)
1. William H. Velander, Henryk Lubon, & William N. Drohan, Transgenic Livestock as Drug Factories, Scientific American, January 1997, 276(1), 70-74.
2. Gary Stix, The Land of Milk & Honey, Scientific American, November 2005, 293(5), 102-104.
3. New Antithrombin Drug, ATryn, Approved by FDA, National Blot Clot Alliance Website.
4. Ian Wilmot, Cloning For Medicine, Scientific American, December 1998, 279(6), 58-63.
5. GM Salmon: FDA's Assessment of Risks, Los Angeles Times, December 24, 2012.
6. Amy Maxmen, Politics Holds Back Animal Engineers, Nature, October 18, 2012, 490, 318-319.
Discussion Seven: Stem Cells & Genetic Engineering
(click here to download the articles)
1. Clive Cookson et al., The Future of Stem Cells. Scientific American Special Report, July, 2005, A6-A21.
2. Konrad Hochedlinger, Your Inner Healers. Scientific American, May, 2010, 302(4), 47-53.
3. Stephen S. Hall, Diseases in a Dish. Scientific American, March, 2011, 304(3), 41-45.
4. Andrew Pollack, Study Says New Method Could Be a Quicker Source of Stem Cells. New York Times, January 29, 2014.
5. Robin Marantz Henig, Cloning is Used to Create Embryonic Stem Cells. New York Times, May 15, 2013.
6. Robin Marantz Henig, Pandora's Baby. Scientific American, June, 2003, 266(6), 63-68.
7. David G. Savage, Supreme Court Rejects Challenge to Obama Stem Cell Policy. Los Angeles Times, January 7, 2013.
8. Eliot Marshall, Historic Patent on Embryonic Stem Cells Faces Scrutiny.Sciences, January 2014, 343(24), 359.
Discussion Eight: Human Genetic Engineering
(click here to download the articles)
1. Inder M. Verma, Gene Therapy. Scientific American, November, 1990, 263(5), 68-84.
2. Steve Mirsky & John Rennie, What Cloning Means for Gene Therapy? Scientific American, June, 1997, 276(6), 122-123.
3. Gary Stix, Hitting the Genetic Off Switch, Scientific American, October, 2004, 291(4), 98-101.
4. Immune Systems of "Bubble Baby" Restored by Gene Therapy, UCLA News, September 14, 2012.
5. Gene Therapy Trial 'Cures Children', BBC News, July 11, 2013.
6. First microRNA Mimic Enters Clinic, Nature Biotechnology, July, 2013, 31(7), 577.
Discussion Nine: Genes and Cancer
(click here to download the articles)
1. Webster K. Cavenee & Raymond L. White, The Genetic Basis of Cancer, Scientific American, March 1995, 273(3), 72-79.
2. Francis S. Collins & Anna D. Barker, Mapping the Cancer Genome, Scientific American, March 2007, 296(3), 50-57.
3. Why Everyone Seems to Have Cancer, The New York Times, January 4, 2014.
4. A Catalog of Cancer Genes That's Done, or Just a Start, The New York Times, February 4, 2014.
5. In Israel, a Push to Screen for Cancer Gene Leaves Many Conflicted, The New York Times, November 26, 2013.
6. In Girl's Last Hope, Altered Immune Cells Beat Leukemia, The New York Times, December 9, 2012.
Discussion Ten: Patenting Genes
(click here to download the articles)
1. Science: Test-Tube Life: Reg. U.S. Pat. Office, Time Magazine, June 30,1980.
2. Gary Stix, Owning the stuff of Life, Scientific American, February, 2006, 294(2), 76-83.
3. Adam Liptak, Justics, 9-0, Bar Patenting Human Genes, New York Times, June 13, 2013.
4. Eleonore Pauwels, Our Genes, Their Secrets, New York Times, June 18, 2013.
5. Andrew Pollack, After Patent Ruling, Availability of Gene Tests Could Broaden, New York Times, June 13, 2013.
6. The Future of Gene Patents and the Implications for Medicine, JAMA Internal Medicine, 2012 17:1569-1570.