Honors Collegium 70A
Genetic Engineering in Medicine, Law, & Agriculture
Winter 2018


Professor Bob Goldberg

SPONSORED BY



Course Documents

 
Course Info:
  Units: 5.0
  Lectures: Tuesday & Thursday : 3:30 - 6:00 PM
  Location: La Kretz 120
  Discussions: Wednesday: 1:00 - 2:50 PM (La Kretz 100)
Wednesday: 3:00 - 4:50 PM (La Kretz 100)

  Office Hours: Friday: 1:00PM - 2:30PM Dr. Bob Goldberg (Terasaki Life Sci 4121)
Class Syllabus

 

 

Class Handouts and Powerpoint Presentation

Week 1

 

01/09/18 - Lecture One Handout (pdf): The Age of DNA: What is Genetic Engineering? (Part One)
01/11/18 - Film:  Race For the Double Helix

 

Week 2

 

01/16/18 - Lecture Two Handout (pdf): The Age of DNA: What is Genetic Engineering? (Part Two)
01/18/18 - Film:  Extraordinary Measures

 

Week 3

 

01/23/18 - Lecture Three Handout (pdf): What Are Genes & How Do They Work: (Part One)
01/25/18 - Guest Speaker:  Dr. Richard Hamilton

 

Week 4

 

01/30/18 - Lecture Four Handout (pdf): What Are Genes & How Do They Work: (Part Two)
02/01/18 -
Film:  Food Evolution
                  Guest Speaker:  Scott Hamilton Kennedy, Drictor "Food Evolution"

 

Week 5

 

02/06/18 - Lecture Five Handout (pdf): How Are Genes Cloned & Engineered: The Hemophilia Story
02/08/18 - Guest Speaker: Harry Klann, Supervising Criminologist, LAPD DNA Unit

 

Week 6

 

02/13/18 - All-Class Midterm Oral Exam
02/15/18 - Film:  Knowledge or Certainty

 

Week 7

 

02/20/18 - Lecture Six Handout (pdf): Twenty-First Century Genetic Engineering Applications
02/22/18 - Lecture Seven Handout (pdf): Age of Genomics: Three Parent Babies, Human Origins, and Race

 

Week 8

 

02/27/18 - Lecture Eight Handout (pdf) by Dr. John Harada: Human Genetic Engineering & Gene Therapy
03/01/18 - Guest Speaker: Stem Cell Biology and Ethics by Dr. Pei Yun Lee

 

Week 9

 

03/06/18 - Lecture Nine Handout (pdf): Science & the Constitution: Regulating Science & GMO
03/08/18 - Guest Speaker: The Future of Genetic Engineering & Health by Dr. Daisy Robinton

 

Week 10

 

03/13/18 - Lecture Ten Handout (pdf): Science & the Constitution: Who Owns Your Genes
03/15/18 - All-Class Final Oral Exam

 

 
Articles For Discussion
 
Discussion One: What Do You Think About Genetic Engineering and GMOs?
 
Discussion Two: Origins of Genetic Engineering - 1
   
1. Stanley N. Cohen, The Manipulation of Genes, Scientific American, June, 1992, 233(1), 24-33.
   
2. Clifford Grobstein, The Recombinant DNA Debate, Scientific American, July, 1977, 237(1), 22-33.
 
Discussion Three: Origins of Genetic Engineering - 2
   
1. Walter Gilbert and Lydia Villa-Komaroff, Useful Proteins From Recombinant Bacteria, Scientific American, April, 1980, 242(4), 74-94.

Discussion Four: Genetic Engineering Crops & Farm Animals
   
1. David H. Freedman, Are Geneticcally Engineered Foods Evil?, Scientific American, September, 2013, 80-85.
   
2. William H. Velander, Henryk Lubon, & William N. Drohan, Transgenic Livestock as Drug Factories, Scientific American, January 1997, 276(1), 70-74.
   
3. Emily Waltz, GM Salmon Declared Fit For Dinner Plates, Nature Biotechnology, January 2016, 7-9.
 
Discussion Five: DNA and the Law
   
1. Peter J. Neufeld & Neville Coleman, When Science Takes the Witness Stand, Scientific American, May, 1990, 262(5), 46-53.
   
2. Caitlin Smith, Stephen Strauss, & Laura DeFrancesco, DNA Goes to Court, Nature Biotechnology, November, 2012, 30(11), 1047-1052.
   
3. Jeffrey Kluger, Science May Make it Impossible to Get Away With a Crime, Time Magazine, July 28, 2017.
 
Discussion Six: How to Mark Your Genes
   
1. Ray White & Jean-Marc Lalouel, Chromosome Mapping with DNA Markers, Scientific American, February 1988, 258(2), 40-48.
   
2. Kevin A. Strauss, Genomics for the People, Scientific American, December 2015, 313(6), 66-73.
   
3. Bonnie Rochman, Should Babies Be Sequenced? Scientific American, March 2017, 316: 72-75.
 
Discussion Seven: Human Gene Therapy - The Beginning
   
1. Inder M. Verma, Gene Therapy. Scientific American, November, 1990, 263(5), 68-84.
   
2. Rick Lewis, Gene Therapy's Second Act, Scientific American, March 1, 2014, 310(3).
 
Discussion Eight: Human Gene Therapy - Twenty-First Century Applications
   
1. Leonard Petrucelli & Aaron D. Gitler, Unlocking The Mystery of ALS, Scientific American, June, 2017.
   
2. Elie Dolgin, The Hexanucleotide Hex, Nature, October 19, 2017.
   
3. Avery D. Posey, Jr., Carl H. June, & Bruce L. Levine Cancer Killers, Scientific American, March, 2017.
 
Discussion Nine: The CRISPR Revolution
   
1. Michael Specter, DNA Revolution, National Geographic Magzine, August 2016, 31-55.
   
2. Annie Sneed, Mail-Order CRISPR Kits Allow Absolutely Anyone to Hack DNA, Scientific American, November 2, 2017.
   
3. Michael Specter, The Gene Hackers, The New Yorker, November 16, 2015.
 
Discussion Ten: Patenting Genes
   
1. John S. Demott, Science: Test-Tube Life: Reg. U.S. Pat. Office, Time Magazine, June 30,1980.
   
2. Gary Stix, Owning the stuff of Life, Scientific American, February, 2006, 294(2), 76-83.
   
3. Adam Liptak, Justics, 9-0, Bar Patenting Human Genes, New York Times, June 13, 2013.
   
4. Antonio Regalado, CRISPR Patent Fight Now a Winner-Take-All Match, MIT Technology Review, April 15, 2015.
   
5. Andrew Pollack, Harvard and MIT Scientists Win Gene-Editing Patent Fight, New York Times, February. 15, 2017.