Welcome to the Drosophila Brain Lineage Atlas

Neurons of the Drosophila central brain are comprised of approximately 100 paired groups, called lineages. Each lineage develops from a single, asymmetrically-dividing stem cell known as a neuroblast. Neurons of one lineage form a developmental unit, as well as a structural unit, sharing many aspects of their projection pattern and connectivity. To learn about the projection pattern of lineages (which are small in number) helps as a first step towards reconstructing and understanding all neurons (of which there are many). The Drosophila Brain Lineage Atlas is intended as a primer to get to know the lineages of the fly brain.

For more detailed information on the structure and development of Drosophila brain lineages please consult the following papers and reviews:

Pereanu, W., Hartenstein, V., 2006. Neural lineages of the Drosophila brain: a three-dimensional digital atlas of the pattern of lineage location and projection at the late larval stage. J. Neurosci. 26, 5534-5553. Pubmed

Ito, K., Awasaki, T. 2008. Clonal unit architecture of the adult fly brain. Adv. Exp. Med. Biol. 628, 137-158. Pubmed

Hartenstein, V., Spindler, S., Pereanu, W., Fung, S. 2008. The development of the Drosophila larval brain. Adv. Exp. Med. Biol. 628, 1-31. Pubmed

Larsen, C., Shy, D., Spindler, S.R., Fung, S., Pereanu, W., Younossi-Hartenstein, A., Hartenstein, V. 2009. Patterns of growth, axonal extension, and axonal arborization of neuronal lineages in the developing Drosophila brain. Dev. Biol. 335, 289-304. Pubmed

Spindler, S.R., Hartenstein, V. 2010. The Drosophila neural lineages: a model system to study brain development and circuitry. Dev. Genes Evol. 220, 1-10. Pubmed

Pereanu, W., Kumar, A., Jennett, A,. Reichert, H., Hartenstein, V., 2010. Development-based compartmentalization of the Drosophila central brain. J. Comp. Neurol. 518, 2996-3023. Pubmed

Lovick J.K., Ngo, K.T.,Omoto, J.J., Wong, D.C., Nguyen, J.D., Hartenstein, V., 2013. Postembryonic lineages of the Drosophila brain: I. Development of the lineage-associated fiber tracts. Dev. Biol. http://dx.doi.org/10.1016/j.ydbio.2013.07.008. Pubmed

Wong, D.C., Lovick, J.K., Ngo, K.T., Borisuthirattana, W., Omoto, J.J., Hartenstein, V. 2013. Postembryonic lineages of the Drosophila brain: II. Identification of lineage projection patterns based on MARCM clones. Dev. Biol. http://dx.doi.org/10.106/j.ydbio.2013.07.009. Pubmed