Selected Publications


Madigan, C.A., Cambier, C.J., Kelly-Scumpia, KM, Scumpia, P.O., Cheng, T.Y., Zailaa, J., Bloom, B.R., Moody, D.B., Smale, S.T., Sagasti, A., Modlin, R.L., and L. Ramakrishnan (2017). A macrophage response to mycobacterium leprae phenolic glycolipid initiates nerve damage in leprosy. Cell 170(5): 973-985. pdf

Vargas, M.E., Yamagashi, Y., Tessier-Lavigne, M and A. Sagasti (2015). Live imaging of calcium dynamics during axon degeneration reveals two functionally distinct phases of calcium influx. Journal of Neuroscience 35(45):15026 –15038. pdf

Rasmussen, J.P., Sack, G.S., Martin, S.M. and A. Sagasti (2015). Vertebrate epidermal cells are broad specificity phagocytes that clear sensory axon debris. Journal of Neuroscience 35(2):559-70. pdf

O’Donnell, K.C., Lulla, A., Stahl, M.C., Wheat, N.D., Bronstein, J.M., and A. Sagasti (2014). Axon degeneration and PGC-1α-mediated protection in a vertebrate model of α-synuclein toxicity. Disease Models and Mechanisms 7(5):571-82 pdf

O'Donnell, K.C., Vargas, M.E., and A. Sagasti (2013). WldS and PGC-1α Regulate Mitochondrial Transport and Oxidation State after Axonal Injury. Journal of Neuroscience. 33(37):14778-90. pdf

Palanca, A.M.S. and A. Sagasti (2013). Optogenetic activation of zebrafish somatosensory neurons using ChEF-tdTomato. JoVE, 71: 10.3791/50184. link

Palanca, A.M.S., Lee, S.L., Yee, L.E., Joe-Wong, C., Trinh, L.A., Hiroyasu, E., Husain, M., Fraser, S.E., Pellegrini, M. and A. Sagasti (2013). New transgenic reporters identify somatosensory neuron subtypes in larval zebrafish. Developmental Neurobiology 73(2): 152-167. pdf

Villegas, R.,* Martin, S.M.,* O'Donnell, K., Carrillo, S., Sagasti, A.# and M.L. Allende# (2012). Dynamics of degeneration and regeneration in developing zebrafish peripheral axons reveals a requirement for extrinsic cell types. Neural Development 8;7(1):19. pdf

Wang, F., Wolfson, S.N., Gharib, A, and A. Sagasti (2012).  LAR Receptor Tyrosine Phosphatases and HSPGs Guide Peripheral Sensory Axons to the Skin. Current Biology, 22(5):373-82. pdf

O'Brien, G.S., Rieger, S., Wang, F., Smolen, G.A., Gonzalez R.E., Buchanan J., and A. Sagasti (2012).  Coordinate development of skin cells and cutaneous sensory axons in zebrafish. Journal of Comparative Neurology, 520(4):816-31.pdf

Rieger, S. and A. Sagasti (2011).  Hydrogen peroxide promotes injury-induced peripheral sensory axon regeneration in the zebrafish skin. PLoS Biology, 9(5):e1000621. pdf

Martin, S.M., O'Brien, G.S., Portera-Cailliau, C., and A. Sagasti (2010).  Wallerian degeneration of zebrafish trigeminal axons in the skin is required for regeneration and developmental pruning. Development,137(23):3985-94. pdf

O’Brien, G.S., Martin S.M., Sollner, C., Wright, G.J., Becker, C.G., Portera-Cailliau, C. and A. Sagasti (2009). Developmentally Regulated Impediments to Skin Reinnervation by Injured Peripheral Sensory Axon Terminals.  Current Biology, 19(24):2086-90. pdf

O'Brien G.S., Rieger S., Martin S.M., Cavanaugh A.M., Portera-Cailliau C., and A. Sagasti (2009). Two-photon axotomy and time-lapse confocal imaging in live zebrafish embryos. JoVE,  24: 10.3791/1129. link

Sagasti, A., Guido, M.R., Raible, D.W., and A.F. Schier (2005).  Repulsive interactions shape the morphologies and functional arrangement of zebrafish peripheral sensory arbors.  Current Biology, 10: 804-814. pdf

Original Research


Grueber, W.B and A. Sagasti (2010).  Self-avoidance and Tiling: Mechanisms of Dendrite and Axon Spacing.  Cold Spring Harb Perspect Biol. 2(9):a001750. pdf

Julien D.P., and A. Sagasti (2014). Synaptic specificity: when the neighbors are away, sensory axons turn promiscuous. Current Biology 24(24):R1168-70. pdf

Wang F., Julien D.P., and A. Sagasti (2013) Journey to the skin: Somatosensory peripheral axon guidance and morphogenesis.  Cell Adhesion and Migration 7(4):388-94 pdf

Rieger, S., Wang, F. and A. Sagasti (2011). Time-lapse imaging of neural development:  Zebrafish lead the way into the fourth dimension.  Genesis 49(7):534-45. pdf

O'Brien, G.S. and A. Sagasti (2009). Fragile axons forge the path to gene discovery: a MAP kinase pathway regulates axon regeneration. Science Signaling 2(69): 30. pdf

Sagasti, A. (2007).  Three ways to make two sides:  genetic models of asymmetric nervous system development.  Neuron  55: 345-351. pdf

Rasmussen, J.P., and A. Sagasti (2016). Learning to swim, again: Axon regeneration in fish. Exp Neurol. pii: S0014-4886(16)30044-9. doi: 10.1016/j.expneurol.2016.02.022. [Epub ahead of print] pdf