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Andrew Goldstein
Phone: 310-206-1402
Office: 3141 Terasaki Life Sciences Building

Education

B.A., Dartmouth College, Biochemistry And Molecular Biology 2005
Ph.D., UCLA, Molecular Biology 2011

Research Interests

The research in the Goldstein laboratory is focused on the intersection between cancer biology, stem cell biology and metabolism. During his graduate work, Dr. Goldstein described the isolation of epithelial progenitor cells from mouse and human prostate tissue and demonstrated the capacity or progenitor cells to initiate prostate cancer in response to oncogenic transformation. Following up on this work, Dr. Goldstein and colleagues determined that prostate cancer can evolve from a basal cell of origin to a luminal-like tumor-propagating cell population. More recently, the Goldstein laboratory has been investigating the interplay between inflammation, epithelial progenitor cells, and tumorigenesis, using a combination of mouse and human tissue models. The main goals of the lab are to elucidate the cellular and molecular mechanisms promoting epithelial cancer initiation, progression and resistance to treatment.

Selected Publications

Crowell PD, Goldstein AS, "Functional evidence that progenitor cells near sites of inflammation are precursors for aggressive prostate cancer", Mol Cell Oncol 4 (2): (2017). [link]

Francoise Remacle, Andrew S. Goldstein, Raphael D. Levine, "Multivariate Surprisal Analysis of Gene Expression Levels", Entropy 18 (12): (2016). [link]

Xian Liu, Tristan R. Grogan, Haley Hieronymus, Takao Hashimoto, Jack Mottahedeh, Donghui Cheng, Lijun Zhang, Kevin Huang, Tanya Stoyanova, Jung Wook Park, Ruzanna O. Shkhyan, Behdokht Nowroozizadeh, Matthew B. Rettig, Charles L. Sawyers, David Elashoff, Steve Horvath, Jiaoti Huang, Owen N. Witte, Andrew S. Goldstein, "Low CD38 Identifies Progenitor-like Inflammation-Associated Luminal Cells that Can Initiate Human Prostate Cancer and Predict Poor Outcome", Cell Reports 17 (10): 2596-2606 (2016). [link]

Stoyanova T, Riedinger M, Lin S, Faltermeier CM, Smith BA, Zhang KX, Going CC, Goldstein AS, Lee JK, Drake JM, Rice MA, Hsu EC, Nowroozizadeh B, Castor B, Orellana SY, Blum SM, Cheng D, Pienta KJ, Reiter RE, Pitteri SJ, Huang J, Witte ON, "Activation of Notch1 synergizes with multiple pathways in promoting castration-resistant prostate cancer", Proc Natl Acad Sci U S A 113 (42): E6457-E6466 (2016). [link]

Zong Y, Goldstein AS, Witte ON, "Preparation of Urogenital Sinus Mesenchymal Cells for Prostate Tissue Recombination Models", Cold Spring Harb Protoc 11: 988-990 (2015).

Zong Y, Goldstein AS, Witte ON, "Dissociated Prostate Regeneration under the Renal Capsule", Cold Spring Harb Protoc 11: 991-994 (2015).

Strand DW, Goldstein AS, "The many ways to make a luminal cell and a prostate cancer cell", Endocr Relat Cancer 22: T187-T197 (2015).

Liu X, Goldstein AS, "Inflammation promotes prostate differentiation", PNAS USA 111: 1666-1667 (2014). [link]

Stoyanova T, Goldstein AS, "Distinct phases of human prostate cancer initiation and progression can be driven by different cell-types", Cancer Cell Microenviron 1: (2014).

Janzen DM, Cheng D, Schafenacker AM, Paik DY, Goldstein AS, Witte ON, Jaroszewicz A, Pellegrini M, Memarzadeh S, "Estrogen and progesterone together expand murine endometrial epithelial progenitor cells", Stem Cells 31: 808-822 (2013).

Stoyanova T, Cooper AR, Drake JM, Liu X, Armstrong AJ, Pienta KJ, Zhang H, Kohn DB, Huang J, Witte ON, Goldstein AS, "Prostate cancer originating in basal cells progresses to adenocarcinoma propagated by luminal-like cells", PNAS USA 110 (50): 20111-20116 (2013). [link]

Zong Y, Goldstein AS, Huang J, "The molecular basis for ethnic variation and histological subtype differences in prostate cancer", Sci China Life Sci 56: 780-787 (2013).

Stoyanova TI, Goldstein AS, "Identification, characterization and targeting of Docetaxel-resistant prostate cancer cells", Asian J Androl 15: 83-84 (2013).

Goldstein AS, "A symbiotic relationship between epithelial and stromal stem cells", PNAS USA 110: 20356-20357 (2013). [link]

Zong Y, Goldstein AS, "Adaptation or selection: Mechanisms of castration-resistant prostate cancer", Nature Reviews Urology 10: 90-98 (2013).