Leanne Jones
Phone: 206-7066
Office: 5139 Terasaki Life Science Bldg.

Education

PhD, Harvard University, Microbiology And Molecular Geneticss
BS, Washington and Lee University, Biology

Research Interests

Stem cells are the building blocks during development of organisms as varied as plants and humans. In addition, stem cells provide for the maintenance and regeneration of tissues, such as blood and skin, throughout the lifetime of an individual. The ability of stem cells to contribute to these processes depends on their ability to divide and generate both new stem cells (self-renewal) as well as specialized cell types (differentiation). The Jones lab uses the fruit fly Drosophila melanogaster and mammalian pluripotent stem cells as model systems to establish paradigms for how stem cell behavior is controlled.

Selected Publications

Resende, L.P.F., Boyle, M., Tran, D., Fellner, T. & Jones, D. L., "Headcase promotes cell survival and niche maintenance in the Drosophila testis", PLoS One 8 (7): (2013).

J.H. Hur, S. Bahadorani, J. Graniel, C.L. Koehler, M. Ulgherait, M. Rera, D.L. Jones, and D.W. Walker, "Increased food intake and longevity mediated by yeast NDI1 expression in Drosophila intestinal stem and progenitor cells", Aging 5 (9): (2013).

H. Toledano, C. D'Alterio, M. Loza-Coll, and D.L. Jones, "Dual fluorescent detection of protein and RNA in Drosophila tissues", Nature Protocols 7: 1808-1817 (2012).

H. Toledano, C. D'Alterio, B. Czech, E. Levine, and D.L. Jones, "The let-7-Imp axis regulates aging of the Drosophila testis stem cell niche", Nature 485: 605-610 (2012).

C. Wong and D.L. Jones, "Efficiency of spermatogonial dedifferentiation during aging", PLoS One 7 (3): (2012).

L. P. Resende and D.L. Jones, "Local Signaling within stem cell niches: lesson from Drosophila", Curr. Op. in Cell Biol 24 (2): 225-231 (2012).

D.L. Jones and T.A. Rando, "Emerging models and paradigms of stem cell ageing", Nat Cell Biol 13: 506-512 (2011).

M. Reya, S. Bahadorani, J. Cho, C. Koehler, M. Ulgherait, J.H. Hur, W. S. Ansari, T. L. Lo, Jr., D. L. Jones* & Walker, D.W.*, "Modulation of longevity and tissue homeostasis by the Drosophila PGC-1 homolog", Cell Metabolism 14: 623-634 (2011).

L. Wang, C.J. McLeod, D.L. Jones, "Regulation of adult stem cell behavior by nutrient signaling", Cell Cycle 10 (16): 2628-2634 (2011).

L. Wang and D.L. Jones, "The relationship between stem cells and aging in Drosophila", Experimental Gerontology (2010).

C. McLeod, L. Wang, C. Wong, and D. L. Jones, "Stem cell dynamics in response to nutrient availability", Current Biology 20: 1-6 (2010).

W. Mair, C. McLeod, L. Wang, and D. L. Jones, "Dietary restriction enhances germline stem cell maintenance", Aging Cell 9 (5): 916-918 (2010).

H. Jasper and D.L. Jones, "Metabolic regulation of stem cell behavior and implications for longevity", Cell Metabolism 10: 561-565 (2010).

J. Voog and D.L. Jones, "Stem cells and the Niche: a dynamic duo", Cell Stem Cell 6: 103-115 (2010).

H. Toledano and D.L. Jones, "Mechanisms regulating stem cell polarity and the specification of asymmetric divisions", StemBook (2009).