Ph.D., University of California, Davis, Plant Molecular Biology 2008
We follow questions of form that capture our minds and hearts and wield quantitative tools to craft new hypotheses about our world. This means we apply and develop quantitative methods, utilise the best biological system to answer our question, and constantly look both forwards and backwards to identify key concepts and tools in the field. We are dynamic, just like our systems!
In all organisms, the growing of a shape is a complex process requiring specific gene products, signaling, mechanical alterations, and coordination of cell growth. Our Team addresses this fundamental process in biology using a multidisciplinary approach including: plant physiology, biochemistry, genetics, molecular biology, materials science, and physics. We focus on understanding how shapes are generated in walled organisms: plants and alage.
For a plant and algal cells, the cell wall is the main structural element, controlling shape and growth of the cell and therefore tissue as a whole. Recent work in plants has correlated key aspects of organ growth and shape generation, in plants, with mechanical properties of tissues and cell walls. Our Team has two main goals: 1) to understand the mechanics of shape growth in plants and algae, and 2) to understand the cell wall as a dynamic composite material.
G Arsuffi, SA Braybrook, "Acid growth: an ongoing trip", Journal of Experimental Botany 69 (2): 137-146 (2018). [link]
TA Torode, RE O'Neill, SE Marcus, V Cornuault, S Pose-Albacete, RP Lauder, SK Kracun, MG Rydahl, MCF Andersen, WGT Willats, SA Braybrook, BJ Townsend, MH Clausen, JP Knox, "Branched pectic galactan in phloem-sieve-element cell walls: implications for cell mechanics", Plant Physiology (2017). [link]
M Linardic SA Braybrook, "Towards an understanding of spiral patterning in the Sargassum muticum shoot apex", Scientific Reports 7: (2017). [link]
R Carter, H Woolfenden, A Baillie, S Amsbury, S Carroll, E Healicon, S Sovatzoglou, SA Braybrook, JE Gray, J Hobbs, RJ Morris, AJ Fleming, "Stomatal Opening Involves Polar, Not Radial, Stiffening Of Guard Cells", Current Biology 27 (19): 2974-2983.e2 (2017). [link]
SA Braybrook, "Plant Development: Lessons from Getting It Twisted", Current Biology 27 (15): R758-R760 (2017). [link]
A Bucksch, A Atta-Boateng, A F Azihou, D Battogtokh, A Baumgartner, B M Binder, S Braybrook, C Chang, V Coneva, T DeWitt, A Fletcher, M Gehan, D H Diaz Martinez, L Hong, A Iyer-Pascuzzi, LL Klein, S A Leiboff, M Li, J Lynch, A Maizel, J N Maloof, RJ C Markelz, C Martinez, L A Miller, W Mio, W Palubicki, H Poorter, C Pradal, C Price, E Puttonen, J Reese, R Rell?n-?lvarez, E P Spalding, E E. Sparks, C N Topp, J H Williams, D H Chitwood, "Morphological plant modeling: Unleashing geometric and topological potential within the plant sciences", Frontiers in Plant Science (2017). [link]
SA Braybrook, "Analysing cell wall elasticity after hormone treatment: an example using tobacco BY-2 cells and auxin", In: Methods in Molecular Biology: Plant Hormones 1497: 125-133 (2016). [link]
SA Braybrook, H Jonsson, "Shifting foundations: the mechanical cell wall and development", Current Opinion in Plant Biology 29: 115-120 (2016). [link]
F Bou Daher, SA Braybrook, "How to let go: pectin and plant cell adhesion", Frontiers in Plant Science 6: (2015). [link]
K Mueller, G Levesque-Tremblay, SA Braybrook, J Pelloux, "Tuning of pectin methylesterification: consequences for cell Wall biomechanics and development", Planta 242 (4): 791-811 (2015). [link]
Z Kong, M Ioki, SA Braybrook, S Li, Z-H Ye, Y-RJ Lee, T Hotta, A Chang, J Tian, G Wang, B Liu, "Kinesin-4 functions in vesicular transport on cortical microtubules and regulates cell wall mechanics during cell elongation in plants", Molecular Plant 8 (7): 1011-1023 (2015). [link]
A Weber, SA Braybrook, M Huflejt, G Mosca, A Routier-Kierzkowska,RS Smith., "Measuring the mechanical properties of plant cells by combining micro-indentation with osmotic treatments", Journal of Experimental Botany 66 (11): 3229-3241 (2015). [link]
P Milani, SA Braybrook, and A Boudaoud, "Shrinking the hammer: micromechanical approaches to morphogenesis", Journal of Experimental Botany 64 (15): 4651-4662 (2013). [link]
SA Braybrook, A Peaucelle, ". Mechano-chemical aspects of organ formation in Arabidopsis thaliana: the relationship between auxin and pectin", PLoS ONE 8 (3): (2013). [link]
SA Braybrook, H Hofte, A Peaucelle., "Probing the mechanical contributions of the pectin matrix: insights for cell growth", Plant, Signaling, and Behavior 3: 1037-1041 (2012). [link]