PhD, Microbiology And Molecular Geneticss, Harvard University 0000
BS, Biology, Washington and Lee University 0000
Stem cells are the building blocks during development of organisms as varied as plants and humans. In addition, stem cells provide for the maintenance and regeneration of tissues, such as blood and skin, throughout the lifetime of an individual. The ability of stem cells to contribute to these processes depends on their ability to divide and generate both new stem cells (self-renewal) as well as specialized cell types (differentiation). The Jones lab uses the fruit fly Drosophila melanogaster and mammalian pluripotent stem cells as model systems to establish paradigms for how stem cell behavior is controlled.
Resende, L.P.F., Boyle, M., Tran, D., Fellner, T. & Jones, D. L., "Headcase promotes cell survival and niche maintenance in the Drosophila testis", PLoS One, 8 (7): e68026- (2013) .
J.H. Hur, S. Bahadorani, J. Graniel, C.L. Koehler, M. Ulgherait, M. Rera, D.L. Jones, and D.W. Walker, "Increased food intake and longevity mediated by yeast NDI1 expression in Drosophila intestinal stem and progenitor cells", Aging, 5 (9): (2013) .
H. Toledano, C. D'Alterio, M. Loza-Coll, and D.L. Jones, "Dual fluorescent detection of protein and RNA in Drosophila tissues", Nature Protocols, 7 : 1808-1817 (2012) .
H. Toledano, C. D'Alterio, B. Czech, E. Levine, and D.L. Jones, "The let-7-Imp axis regulates aging of the Drosophila testis stem cell niche", Nature, 485 : 605-610 (2012) .
C. Wong and D.L. Jones, "Efficiency of spermatogonial dedifferentiation during aging", PLoS One, 7 (3): e33635- (2012) .
L. P. Resende and D.L. Jones, "Local Signaling within stem cell niches: lesson from Drosophila", Curr. Op. in Cell Biol, 24 (2): 225-231 (2012) .
D.L. Jones and T.A. Rando, "Emerging models and paradigms of stem cell ageing", Nat Cell Biol, 13 : 506-512 (2011) .
M. Reya, S. Bahadorani, J. Cho, C. Koehler, M. Ulgherait, J.H. Hur, W. S. Ansari, T. L. Lo, Jr., D. L. Jones* & Walker, D.W.*, "Modulation of longevity and tissue homeostasis by the Drosophila PGC-1 homolog", Cell Metabolism, 14 : 623-634 (2011) .
L. Wang, C.J. McLeod, D.L. Jones, "Regulation of adult stem cell behavior by nutrient signaling", Cell Cycle, 10 (16): 2628-2634 (2011) .
L. Wang and D.L. Jones, "The relationship between stem cells and aging in Drosophila", Experimental Gerontology, (2010) .