Selected Publications
2009

Yang H, Xiang J, Wang N, Zhao Y, Hyman J, Li S, Jiang J, Chen JK, Yang Z, Lin S. (2009) Converse conformational control of smoothened activity by structurally related small molecules. J Biol Chem. 284(31):20876-84. Epub 2009 Apr 14.


Gomez GA, Veldman MB, Zhao Y, Burgess S, Lin S. (2009) Discovery and characterization of novel vascular and hematopoietic genes downstream of etsrp in zebrafish. PLoS One. 2009;4(3):e4994. Epub 2009 Mar 24.


Xiang J, Yang H, Che C, Zou H, Yang H, Wei Y, Quan J, Zhang H, Yang Z, Lin S. (2009) Identifying tumor cell growth inhibitors by combinatorial chemistry and zebrafish assays. PLoS One.;4(2):e4361. Epub 2009 Feb 5.


Bukrinsky A, Griffin KJ, Zhao Y, Lin S, Banerjee U. (2009) Essential role of spi-1-like (spi-1l) in zebrafish myeloid cell differentiation. Blood. 113(9):2038-46. Epub 2009 Jan 8.

2008

Jiang Z, Song J, Qi F, Xiao A, An X, Liu NA, Zhu Z, Zhang B, Lin S. (2008) Exdpf is a key regulator of exocrine pancreas development controlled by retinoic acid and ptf1a in zebrafish. PLoS Biol. Nov 25;6(11):e293.


Danilova N, Sakamoto KM, Lin S. (2008) Ribosomal protein S19 deficiency in zebrafish leads to developmental abnormalities and defective erythropoiesis through activation of p53 protein family. Blood. 112(13):5228-37. Epub 2008 May 30.


Liu NA, Ren M, Song J, RĂ­os Y, Wawrowsky K, Ben-Shlomo A, Lin S, Melmed S. (2008) In vivo time-lapse imaging delineates the zebrafish pituitary proopiomelanocortin lineage boundary regulated by FGF3 signal. Dev Biol. 319(2):192-200. Epub 2008 Apr 9.


Mei J, Zhang QY, Li Z, Lin S, Gui JF. (2008) C1q-like inhibits p53-mediated apoptosis and controls normal hematopoiesis during zebrafish embryogenesis. Dev Biol. 319(2):273-84. Epub 2008 Apr 25.

Wei W, Wen L, Huang P, Zhang Z, Chen Y, Xiao A, Huang H, Zhu Z, Zhang B, Lin S. (2008) Gfi1.1 regulates hematopoietic lineage differentiation during zebrafish embryogenesis. Cell Res. 18(6):677-85.


Lee D, Park C, Lee H, Lugus JJ, Kim SH, Arentson E, Chung YS, Gomez G, Kyba M, Lin S, Janknecht R, Lim DS and Choi K (2008) ER71 acts downstream of BMP, Notch and Wnt signaling in blood and vessel progenitor specification. Cell Stem Cell. 2(5):497-507


Sumanas S, Gomez G, Zhao Y, Park C, Choi K, and Lin S. (2008) Interplay between Etsrp/ER71, scl and alk8 signaling controls endothelial and myeloid cell formation. Blood. 111(9):4500-10.

2007
Yang Z, Jiang H, Zhao F, Shankar D, Sakamoto KM, Zhang MQ, and Lin S. (2007) A highly conserved regulatory element controls hematopoietic expression of GATA-2 in zebrafish. BMC Dev Biol. 7(1):97.

Wang D, Jao LE, Zheng N, Dolan K, Ivey J, Zonies S, Wu X, Wu K, Yang H, Meng Q, Zhu Z, Zhang B, Lin S, and Burgess SM. (2007) Efficient genome-wide mutagenesis of zebrafish genes by retroviral insertions. Proc Natl Acad Sci U S A. 104(30):12428-33 (as corresponding author).

Song J, Kim HJ, Gong Z, Liu NA, and Lin S. (2007) Vhnf1 acts downstream of Bmp, Fgf, and RA signals to regulate endocrine beta cell development in zebrafish. Dev Biol. 303(2):561-75

2006

Zhong H, Wu X, Huang H, Fan Q, Zhu Z,  and Lin S (2006) Vertebrate MAX-1 is required for vascular patterning in zebrafish. Proc Natl Acad Sci U S A. 103(45):16800-5.


Wu X, Zhong H, Song J, Damoiseaux R, Yang Z, and Lin S. (2006) Mycophenolic acid is a potent inhibitor of angiogenesis. Arterioscler Thromb Vasc Biol. 26(10):2414-6.


Yang Z, Jiang H, Chachainasakul T, Gong S, Yang XW, Heintz N, and Lin S. (2006) Modified bacterial artificial chromosomes for zebrafish transgenesis. Methods. 39(3):183


Liu B, Lee KW, Anzo M, Zhang B, Zi X, Tao Y, Shiry L, Pollak M, Lin S, and Cohen P. (2006) Insulin-like growth factor-binding protein-3 inhibition of prostate cancer growth involves suppression of angiogenesis. Oncogene. 26(12):1811-9

 

Zhao Y, Yang Z, Phelan JK, Wheeler DA, Lin S, and McCabe ER. (2006) Zebrafish dax1 is required for development of the interrenal organ, the adrenal cortex equivalent. Mol Endocrinol. 20(11):2630-40


Wan H, Korzh S, Li Z, Mudumana SP, Korzh V, Jiang YJ, Lin S and Gong Z. (2006) Analyses of pancreas development by generation of gfp transgenic zebrafish using an exocrine pancreas-specific elastase A gene promoter. Exp Cell Res. 312(9):1526-39

Kwan TT, Liang R, Verfaillie CM, Ekker SC, Chan LC, Lin S and Leung AYH. (2006) Regulation of primitive hematopoiesis in zebrafish embryos by the death receptor gene. Exp Hematology 34(1):27-34.


Liu NA, Liu Q, Wawrowsky K, Yang Z, Lin S, and Melmed S (2006) Prolactin receptor signaling mediates the osmotic response of embryonic zebrafish lactotrophs. Mol Endocrinol. 20(4):871-80.

 

Sumanas S. and Lin, S. (2006) Ets1-related protein is a key regulator of vasculogenesis in zebrafish. PLoS Biol, 4(1):e10.


Kim HJ, Sumanas S, Palencia-Desai S, Dong Y, Chen JN, and Lin S. (2006) Genetic analysis of early endocrine pancreas formation in zebrafish. Mol Endocrinol. 20 (1): 194-203

2005

Kim HJ, Schleiffarth JR, Jessurun J, Sumanas S, Petryk A, Lin S and Ekker EC (2005) Wnt5 Signaling in Vertebrate Pancreas Development. BMC Biology, 3:23


Sumanas S, Zhang B, Dai R, and Lin S. (2005) 15-Zinc finger protein Bloody Fingers is required for zebrafish morphogenetic movements during neurulation.  Dev Biol. 283(1):85-96.;


Sumanas S, Jorniak T and Lin S, (2005). Identification of novel vascular endothelial-specific genes by the microarray analysis of the zebrafish cloche mutants. Blood, 106(2):534-41


Huang H, Zhang B, Hartenstein PA, Chen JN, and Lin S. (2005) NXT2 is required for embryonic heart development in zebrafish. BMC Dev Biol. 5(1):7.

2004

Shafizadeh E, Peterson RT., and Lin S. (2004) Induction of reversible hemolytic anemia in living zebrafish using a novel small molecule. Comp Biochem Physiol C Toxicol Pharmacol. 138(3):245-9.


Penberthy WT, Zhao C, Zhang Y, Jessen JR, Yang Z, Bricaud O, Collazo A, Meng A and Lin S. (2004) Pur alpha and Sp8 as Opposing Regulators of Neural GATA-2 Expression. Dev Biol. 275(1):225-34.


Ransom DG, Bahary N, Niss K, Traver D, Burns C, Trede NS, Paffett-Lugassy N, Saganic WJ, Lim CA, Hersey C, Zhou Y, Barut BA, Lin S, Kingsley PD, Palis J, Orkin SH, Zon LI. (2004) The zebrafish moonshine gene encodes transcriptional intermediary factor 1gamma, an essential regulator of hematopoiesis. PLoS Biol. 2(8):E237.


Pi W, Yang Z, Ruan L, Yu X, Ling J, Isales C, Conway SJ, Lin S and D Tuan (2004) The LTR enhancer of ERV-9 human endogenous retrovirus is active during oogenesis in transgenic zebrafish and human. Proc. Natl. Acad. Sci. USA. 01(3): 805-10.

2003 Traver D, Paw BH, Poss KD, Penberthy WT, Lin S, and Zon LI. (2003) Transplantation and in vivo imaging of multilineage engraftment in zebrafish bloodless mutants. Nat Immunol. 4(12):1238-46.


Langenau DM, Traver D, Ferrando AA, Kutok JL, Aster JC, Kanki JP, Lin S, Prochownik E, Trede NS, Zon LI, and Look AT. (2003) Myc-induced T cell leukemia in transgenic zebrafish. Science. 299:887-90


Liu NA, Huang H, Yang Z, Herzog W, Hammerschmidt M, Lin S, and Melmed S. (2003) Pituitary Corticotroph Ontogeny and Regulation in Transgenic Zebrafish. Mol Endocrinol. 17(5):959-66


Brownlie A, Hersey C, Oates AC, Paw BH, Falick AM, Witkowska HE, Flint J, Higgs D, Jessen J, Bahary N, Zhu H, Lin S, and Zon L. 2003 Characterization of embryonic globin genes of the zebrafish. Dev Biol. 255:48-61.


Cross LM, Cook MA, Lin S, Chen JN, and Rubinstein AL. (2003) Rapid analysis of angiogenesis drugs in a live fluorescent zebrafish assay. Arterioscler Thromb Vasc Biol. 23:911-2.

2002 Shafizadeh, E., Paw, BH., Foott, H., Liao,  EC., Barut, BA., Cope, JJ., Zon, LI., and Lin S. (2002) Characterization of zebrafish merlot/chablis as a non-mammalian vertebrate model for severe congenital anemia due to protein 4.1 deficiency. Development 129:4359-4370


Lee, KY., Huang, H., Ju, BS., Yang Z., and Lin, S. (2002) Cloned zebrafish by nuclear transfer from long-term cultured cells. Nature Biotechnology. 20:795-9.

2001 Huang, H, Liu, N, and Lin, S. (2001) Pdx-1 knockdown reduces insulin promoter activity in zebrafish. Genesis. 30:134-6.


Jessen, JR., Jessen, TN., Vogel, SS., and Lin, S. (2001) Concurrent Expression of Recombination Activating Genes 1 and 2 in Zebrafish Olfactory Sensory Neurons. Genesis 29:156-62.


Yang, Z., Liu, N. and Lin, S. (2001) A zebrafish forebrain-specific zinc finger gene can induce ectopic dlx2 and dlx6 expression. Dev Biol. 231(1):138-148.


Huang, HG., Vogel, SS., Liu, N., Melton, DA., and Lin, S. (2001) Analysis of pancreatic development in living transgenic zebrafish. Mol & Cell. Endocrinology 177:117-24.

2000
Long, Q., Huang, HG., Shafizadeh, E., Liu, N. and Lin, S (2000) Stimulation of erythropoiesis by inhibiting a new hematopoietic death receptor in transgenic zebrafish. Nature Cell Biology 2(8): 549-552.
1999
Jessen, JR., Willett, CE and Lin, S. (1999) Artificial chromosome transgenesis reveals long-distance negative regulation of rag1 in zebrafish. Nature Genetics 23(1):15-16.

Meng, A.,  Moore, B.,  Hong, T.,  Yuan BZ and Lin, S. (1999) A Drosophila doublesex-related gene, terra, is involved in somitogenesis in vertebrates. Development 126(6):1259-1268.

Meng, A. Hong, T., Ong, B., Long, QM. and Lin S. (1999) Positive and negative cis-acting elements are required for hematopoietic expression of zebrafish GATA-1. Blood 93(2):500-8.

1998

Wang, H., Long, QM., Marty, S., Sassa, S. and Lin, S. (1998) A zebrafish model for hepatoerythropoietic porphyria. Nature Genetics  20, 239-243.

Jessen, JR., Meng, AM., McFarlane RJ., Paw, BH., Zon, LI., Smith, G. and Lin, S. (1998) Modification of bacterial artificial chromosomes through chi-stimulated homologous recombination and its application in zebrafish transgenesis. Proc. Natl. Acad. Sci. USA.  95, 5121-5126.

1997
Long, QM., Meng, AM., Wang, H., Jessen, JH., Farrell, MJ. and Lin, S. (1997). GATA-1 expression pattern can be recapitulated in living transgenic zebrafish using GFP reporter gene. Development. 124, 4105-4111.


Meng, A., Tang, H., Ong, BA., Farrell, MJ and Lin, S. (1997). Promoter analysis in living zebrafish embryos identifies a cis-acting motif required for neuronal expression of GATA-2. Proc. Natl. Acad. Sci. USA. 94, 6267-6272.

Post-
doctoral

Lin, S., Gaiano, N., Culp, P., Burns, J., Friedmann, T., Yee, J-K. and N. Hopkins (1994). Integration and germ line transmission of a pseudotyped retroviral vector in zebrafish. Science, 265, 666-668.

Lin S, Yang S, Hopkins N. (1994) lacZ expression in germline transgenic zebrafish can be detected in living embryos. Dev Biol. 161(1):77-83.

Lin, S., Long, W., Chen, J. and N. Hopkins (1992). Production of germ-line chimeras in zebrafish by cell transplants from genetically pigmented to albino embryos. Proc. Natl. Acad. Sci. USA. 89, 4519-4523.