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Pavak Shah
Office: 5000C Terasaki Life Sciences Building
Lab: 5045 Terasaki Life Sciences Building

Education

BS, North Carolina State University, Biomedical Engineering 2009
PhD, University of North Carolina at Chapel Hill and North Carolina State University, Biomedical Engineering 2014

Research Interests

Neurons are highly dynamics cells who produce complex networks of connections. These circuits are continuously refined by developmental events and in response to new experiences, but how do neuronal circuits first acquire their function at the point where none previously existed? What mechanisms then allow a nascent circuit to refine its connectivity and activity to produce coordinated output?

We are exploring these questions using the embryo of the nematode Caenorhabditis elegans as a model. With a combination of methods drawn from classical genetics, the state-of-the-art in quantitative imaging, and new approaches to manipulating single cells in vivo, we are mapping the emergence of functional circuitry in the embryo. While cell adhesion molecules and morphogen gradients may teach us how to ?wire? a brain, we are working to understand how to ?boot? one up.

Selected Publications

Piya Ghose, Alina Rashid, Peter Insley, Meera Trivedi, Pavak Shah, Anupriya Singhal, Yun Lu, Zhirong Bao, Shai Shaham, "EFF-1 fusogen promotes phagosome sealing during cell process clearance in Caenorhabditis elegans", Nature cell biology 20 (4): (2018).

Pavak K Shah, Matthew R Tanner, Ismar Kovacevic, Aysha Rankin, Teagan E Marshall, Nathaniel Noblett, Nhan Nguyen Tran, Tony Roenspies, Jeffrey Hung, Zheqian Chen, Cristina Slatculescu, Theodore J Perkins, Zhirong Bao, Antonio Colavita, "PCP and SAX-3/Robo pathways cooperate to regulate convergent extension-based nerve cord assembly in C. elegans", Developmental Cell 41 (2): 195-203 (2017).

Pavak Kirit Shah, Anthony Santella, Adrian Jacobo, Kimberly Siletti, AJ Hudspeth, Zhirong Bao, "An In Toto Approach to Dissecting Cellular Interactions in Complex Tissues", Developmental cell 43 (4): 530-540 (2017).

Zhuo Du, Anthony Santella, Fei He, Pavak K Shah, Yuko Kamikawa, Zhirong Bao, "The regulatory landscape of lineage differentiation in a metazoan embryo", Developmental cell 34 (5): (2015).

Anthony Santella, Ra?l Catena, Ismar Kovacevic, Pavak Shah, Zidong Yu, Javier Marquina-Solis, Abhishek Kumar, Yicong Wu, James Schaff, Daniel Col?n-Ramos, Hari Shroff, William A Mohler, Zhirong Bao, "WormGUIDES: an interactive single cell developmental atlas and tool for collaborative multidimensional data exploration", BMC Bioinformatics 16 (1): (2015).

Pavak K Shah, Matthew P Walker, Christopher E Sims, Michael B Major, Nancy L Allbritton, "Dynamics and evolution of β-catenin-dependent Wnt signaling revealed through massively parallel clonogenic screening", Integrative Biology 6 (7): (2014).

Pavak K Shah, Silvia Gabriela Herrera‐Loeza, Christopher E Sims, Jen Jen Yeh, Nancy L Allbritton, "Small sample sorting of primary adherent cells by automated micropallet imaging and release", Cytometry Part A 85 (7): (2014).

Yuli Wang, Asad A Ahmad, Pavak K Shah, Christopher E Sims, Scott T Magness, Nancy L Allbritton, "Capture and 3D culture of colonic crypts and colonoids in a microarray platform", Lab on a chip 13 (23): (2013).

Michelle L Kovarik, Pavak K Shah, Paul M Armistead, Nancy L Allbritton, "Microfluidic chemical cytometry of peptide degradation in single drug-treated acute myeloid leukemia cells", Analytical Chemistry 85 (10): (2013).

PK Shah, MR Hughes, Y Wang, CE Sims, NL Allbritton, "Scalable synthesis of a biocompatible, transparent and superparamagnetic photoresist for microdevice fabrication", Journal of Micromechanics and Microengineering 23 (10): (2013).

Yuli Wang, Pavak Shah, Colleen Phillips, Christopher E Sims, Nancy L Allbritton, "Trapping cells on a stretchable microwell array for single-cell analysis", Analytical and bioanalytical chemistry 402 (3): (2012).

Michelle L Kovarik, Douglas M Ornoff, Adam T Melvin, Nicholas C Dobes, Yuli Wang, Alexandra J Dickinson, Philip C Gach, Pavak K Shah, Nancy L Allbritton, "Micro total analysis systems: fundamental advances and applications in the laboratory, clinic, and field", Analytical Chemistry 85 (2): (2012).

Eric D Kaufman, Jennifer Belyea, Marcus C Johnson, Zach M Nicholson, Jennifer L Ricks, Pavak K Shah, Michael Bayless, Torbj?rn Pettersson, Zsombor Feldot?, Eva Blomberg, Per Claesson, Stefan Franzen, "Probing protein adsorption onto mercaptoundecanoic acid stabilized gold nanoparticles and surfaces by quartz crystal microbalance and ζ-potential measurements", Langmuir 23 (11): (2007).