December 10, 2020

9am 10am
Please email mbiasst@lifesci.ucla.edu for Zoom link.

Scott Dehm, Ph.D.
Professor and Apogee Enterprises Chair in Cancer Research, Department of Laboratory Medicine and Pathology, University of Minnesota

"Evolution and Plasticity of the Androgen Receptor in Prostate Cancer"

MBI Research Seminar
Please email mbiasst@lifesci.ucla.edu for Zoom link.

December 3, 2020

9am-10am
Please contact Nadia for zoom information – mbiasst@lifesci.ucla.edu

Samie Jaffrey, M.D., Ph.D.
Professor, Pharmacology, Weill Medical College, Cornell University

"Understanding the function and dynamics of m6A in the epitranscriptome"

MBI Research Seminar
Please contact Nadia for zoom information – mbiasst@lifesci.ucla.edu

November 19, 2020

9am-10am
Please contact Nadia for zoom information – mbiasst@lifesci.ucla.edu

Cecilia Moens, PhD
Professor, Basic Sciences Division, Fred Hutchinson Cancer Research Center

"Transcriptional Regulation of Heart Development and Congenital Heart Disease"

MBI Research Seminar

Zoom – Please contact Nadia for zoom information.
Contact – Nadia Avila – mbiasst@lifesci.ucla.edu

November 12, 2020

9am-10am
Please email mbiasst@lifesci.ucla.edu for Zoom information.

Benoit G. Bruneau, Ph.D.
Director, Gladstone Institute of Cardiovascular Disease/William H. Younger Chair in Cardiovascular Research, Gladstone Institutes/Professor, Department of Pediatrics, UC San Francisco

"Transcriptional regulation of heart development and congenital heart disease"

MBI Research Seminar
Please contact Nadia for zoom information. Contact – – Nadia Avila

November 5, 2020

9am-10am
Please contact Nadia Avila for zoom information.

Cole Trapnell, PhD
Assistant Professor, Genome Sciences, University of Washington

"Embryo-scale, single-cell spatial transcriptomics"

MBI Research Seminar
Please contact Nadia Avila for zoom information.

October 29, 2020

9am-10am
Please email mbiasst@lifesci.ucla.edu for Zoom information

Dominique Missiakas, Ph.D.
Professor, Microbiology, University of Chicago

"A tale of two pathogens: Yersinia pestis and Staphylococcus aureus"

Dominique Missiakas, Ph.D.
Professor, Microbiology
University of Chicago

MBI Seminar Series
Contact – Nadia Avila – mbiasst@lifesci.ucla.edu
Please email mbiasst@lifesci.ucla.edu for Zoom information
Website - https://www.mbi.ucla.edu/seminars/thursday-research-seminars

October 22, 2020

9am-10am
Please email mbiasst@lifesci.ucla.edu for Zoom information

Henry N. Higgs, Ph.D.
Professor, Department of Biochemistry, Geisel School of Medicine at Dartmouth

"Dissecting the mechanisms by which actin influences mitochondria in mammals"

MBI Research Seminar

“Dissecting the mechanisms by which actin influences mitochondria in mammals”

Henry N. Higgs, Ph.D.
Professor, Department of Biochemistry
Geisel School of Medicine at Dartmouth

Please email mbiasst@lifesci.ucla.edu for Zoom information

October 8, 2020

9am-10am
Zoom – Please contact Nadia at mbiasst@lifesci.ucla.edu for zoom information

Pamela Bjorkman, PhD
Professor, Biology and Biomolecular Engineering, Caltech

"Antibody Recognition of Pandemic Viruses"

MBI Research Seminar

Antibody Recognition of Pandemic Viruses
Pamela Bjorkman, PhD
Professor, Biology and Biomolecular Engineering, Caltech

Zoom – Please contact Nadia for zoom information.
Contact – Nadia Avila – mbiasst@lifesci.ucla.edu
Website - https://www.mbi.ucla.edu/seminars/thursday-research-seminars

October 7, 2020

12pm-1pm
Register at uclahs.fyi/ctsi-seminar

William Lowry, Ph.D.
Professor, Molecular, Cell & Developmental Biology

"Manipulating Metabolism in Hair Follicle Stem Cells to Regulate Activation and Tumorigenesis"

CTSI DISTINGUISHED SPEAKER SERIES

Manipulating Metabolism in Hair Follicle Stem Cells to Regulate Activation and Tumorigenesis

William Lowry, Ph.D.
Professor, Molecular, Cell and Developmental Biology
UCLA

Date: October 07, 2020 12:00 PM - 1:00 PM
Location: Register at uclahs.fyi/ctsi-seminar

DGSOM Theme: Cancer
In partnership with the UCLA David Geffen School of Medicine Themes
For additional information, please contact: ctsiseminar@mednet.ucla.edu

October 1, 2020

9AM
Zoom – Please contact Nadia at mbiasst@lifesci.ucla.edu for zoom information

Eric Skaar, PhD, MPH
Vanderbilt University

"Nutritional Immunity and Microbial Countermeasures"

MBI Research Seminar

Nutritional Immunity and Microbial Countermeasures

Eric Skaar, PhD, MPH

Professor & Chair, Pathology and Microbiology, & Immunology

Vanderbilt University

Zoom – Please contact Nadia for zoom information.

Contact – Nadia Avila – mbiasst@lifesci.ucla.edu

Website:  http://www.mbi.ucla.edu/seminars/thursday-research-seminars/

September 14, 2020

11AM
Please contact Rosemary at cri@mednet.ucla.edu for password information

Arjun Deb, MD
Professor, Molecular, Cell & Developmental Biology

"Brief Theme Update: How Heart Scars Regulate Their Own Size"

Cardiovascular Seminar

Brief Theme Update: How Heart Scars Regulate Their Own Size

Arjun Deb, MD

Professor, Molecular, Cell & Developmental Biology,

UCLA College of Letters & Sciences; and

Medicine, Cardiology, David Geffen School of Medicine at UCLA

Zoom –

https://uclahs.zoom.us/j/4675328384?pwd=MkNncmNRV2I2Zk90U1FNMmYyTHh4QT09

Password – Please contact Rosemary for password information.

Contact – Rosemary Portal – cri@mednet.ucla.edu

Website: https://medschool.ucla.edu/cardiovascular-seminar-series

August 25, 2020

12pm (noon)
Meeting ID: 921 7373 2925 Passcode: 755857

Pavak K. Shah, Ph.D.
Assistant Professor, Molecular, Cell and Developmental Biology

"From Structure to Function: Dissecting neural development with in toto imaging"

UCLA Molecular Biology Institute
Faculty Seminar

June 30, 2020

12pm (noon)
Meeting ID: 960 2156 5745 Password: 347454

Tracy Johnson, Ph.D.
Professor, Molecular, Cell & Developmental Biology

"RNA splicing, chromatin modification, and the coordinated control of gene expression"

MBI Faculty Seminar - Tracy Johnson, Ph.D.

Zoom Link: https://ucla.zoom.us/j/96021565745?pwd=UHk3elNobXU5OVEvaFpNNUlmT1BrQT

Meeting ID: 960 2156 5745
Password: 347454

June 10, 2020

3 PM
Meeting ID: 923 8595 2941

Rafael Demarco

"Metabolic regulation of the male germline stem cell niche in Drosophila"

Postdoc Seminar Series
Hosts: Hanna Mikkola and Alvaro Sagasti

June 3, 2020

3 PM
Zoom Meeting ID: 943 0973 7474

Noor Khan
Postdoc, UCLA MCDB

"Microbes replacing synthetic fertilizers and fungicides for sustainable agriculture"

Postdoc Seminar Series
Hosts: Dr. Hanna Mikkola and Dr. Alvaro Sagasti

May 20, 2020

3 PM
via Zoom (Meeting ID: 943 0973 7474)

Sandra Capellera Garcia
Postdoc, UCLA MCDB

"Single cell map of the emergence of human hematopoietic stem cells from hemogenic endothelium"

Postdoc Seminar Series
Hosts: Dr. Hanna Mikkola and Dr. Alvaro Sagasti

May 13, 2020

3 PM
via Zoom (Meeting ID: 943 0973 7474)

Xu Wang
Postdoc, UCLA MCDB

"New mechanism of plant cryptochromes in regulating photo-responsive gene expressions"

Postdoc Seminar Series
Speaker: Xu Wang, Postdoc from Lin's Lab
Hosts: Hanna Mikkola and Alvaro Sagasti

May 6, 2020

3 PM
via Zoom (Zoom Meeting ID: 943 0973 7474)

Erica Pandolfi
Postdoc, UCLA MCDB

"Restoring Germline Potential to Patients Diagnosed with Primary Ovarian Sufficiency"

Hosts: Dr. Hanna Mikkola and Dr. Alvaro Sagasti

April 29, 2020

3 PM
Zoom Meeting ID: 923 8595 2941 Password: 794415

Laurent Voisin
Postdoc, UCLA MCDB

"Cellular cannibalism & senescence"

Postdoc Seminar Series

Hosts: Dr. Hanna Mikkola and Dr. Alvaro Sagasti

April 22, 2020

3 pm
via Zoom (Zoom Meeting ID: 943 0973 7474, Password: 639989)

Jake Harris
Postdoc, UCLA MCDB

"Activation under repression: who wins and why?"

Postdoc Seminar Series

Hosts: Dr. Hanna Mikkola and Dr. Alvaro Sagasti

March 5, 2020

4PM
159 Boyer Hall

Trent Northen, Ph.D.
Chemist Senior Scientist, Environmental Genomics and Systems Biology, DOE Joint Genome Institute

"Exploring the chemistry of microbiomes with mass spectrometry"

Sponsor: MBI - Thursday Research Seminar Series

February 27, 2020

1pm
154 BSRB

Matteo Pellegrini, PhD
UCLA: Prof MCDB

"What Can We Learn About Our Health From DNA Methylation"

Sponsor: OHRC

February 20, 2020

4PM
159 Boyer Hall

Janet Rossant, Ph.D., FRS, FRSC
University of Toronto, Professor, Molecular Genetics, Obstetrics and Gynecology

"Defining totipotency- from embryos to stem cells"

Sponsor: MBIDP
Thursday Seminar Series

February 20, 2020

11:30am
154 BSRB

Michelle Chan, Ph.D.
University of California, San Francisco

"From one cell to many: Deciphering regulation in mammalian development"

Ontogeny describes the emergence of complex multicellular organisms from single totipotent cells. In mammals, this field is particularly challenging due to the indeterminate relationship between self-renewal and differentiation, variation of progenitor field sizes, and internal gestation. Here, we present a flexible, high information, multi-channel molecular recorder with a single cell (sc) readout and apply it as an evolving lineage tracer to define a mouse cell fate map from fertilization through gastrulation. By combining lineage information with scRNA-seq profiles, we recapitulate canonical developmental relationships between different tissue types and reveal the nearly complete transcriptional convergence of endodermal cells from extra-embryonic and embryonic origins. Finally, we apply our cell fate map to estimate the number of embryonic progenitor cells and their degree of asymmetric partitioning during specification. Our approach enables massively parallel, high-resolution recording of lineage and other information in mammalian systems to facilitate a quantitative framework for understanding developmental processes.

Thursday, February 20, 2020
11:30am in 154 BSRB
(Biomedical Research Science Bldg.)
Hosts: Dr. Alexander Hoffmann and Dr. Bill Lowry

Light refreshments

February 18, 2020

12pm (noon)
158 Hershey Hall (Grand Salon)

Manu Setty, Ph.D.
Sloan Kettering Institute, New York, NY

"Characterization of lineage decisions in developmental trajectories using single-cell data"

How a cell decides its lineage is a long-standing and enigmatic question in molecular biology. I will present my research to characterize lineage decisions in developmental trajectories by computational modeling of high throughput data such as single-cell RNA-seq. I will describe Palantir, the first single-cell trajectory detection algorithm to model continuities in lineage decisions. Palantir models differentiation as a Markov process to compute the lineage biases and differentiation potential, a measure of plasticity, for all cells. Palantir modeling enables an accurate identification of lineage decision regions and associated gene expression and regulatory dynamics. I will then describe our study to characterize the spatial and temporal trajectories of mouse endoderm development. Combining Palantir modeling with a large-scale single-cell data, we uncovered an unexpected plasticity of embryonic epiblast cells to differentiate to the surrounding extra-embryonic endoderm at implantation and the concomitant emergence of the spatial signal in the endoderm. Our analysis further demonstrated the convergence of embryonic definitive and extra-embryonic visceral endoderm cells into spatially organized organ territories in the gut-tube at mid-gestation.

February 13, 2020

4pm
159 Boyer Hall

Mitchell Lazar, M.D., Ph.D.
University of Pennsylvania

"Transcriptional Regulation of Circadian Rhythms and Metabolism"

Sponsor: MBIDP - Thursday Research Seminar Series

February 12, 2020

12pm
1357 Gonda

Zeba Wunderlich, Ph.D.
Assistant Professor, Department of Developmental and Cell Biology, University of California, Irvine

"The Connections Between Enhancer Architecture and Function"

To carry out an enormous diversity of tasks, proteins can assume a variety of structures or disordered states, and years of work have made the connection between protein sequences, structures, and functions. Enhancers and other pieces of regulatory DNA regulate gene expression in highly disparate biological processes, but we still lack general principles that can help us connect enhancer sequence, transcription factor binding site arrangement (or architecture), and function. In my seminar, I will share two projects that seek to make connections between the way enhancers are built and the tasks they carry out in two biological settings: early development and the innate immune response in Drosophila. In the first part, I will describe a mechanism by which redundant (shadow) enhancers control expression noise, and in the second, I will describe the patterns of evolution that drive divergence in the expression response to bacterial infection.

February 3, 2020

12pm
158 Hershey Hall (Grand Salon)

Johannes Schöneberg, PhD
UC Berkeley

"Adaptive Optics Lattice Light-Sheet Imaging and AI Powered Big Data Processing of Live Stem Cell-Derived Organoids"

New methods in stem cell 3D organoid tissue culture, advanced imaging, and big data image analytics now allow tissue-scale 4D cell biology but currently available analytical pipelines are inadequate for handing and analyzing the resulting gigabytes and terabytes of high-content imaging data. We expressed fluorescent protein fusions of clathrin and dynamin2 at endogenous levels in genome- edited human embryonic stem cells, which were differentiated into intestinal epithelial organoids. Lattice light-sheet imaging with adaptive optics (AO-LLSM) allowed us to image large volumes of these organoids (70 × 60 × 40 μm xyz) at 5.7 s/frame. We developed an open-source data analysis package termed pyLattice to process the resulting large (∼60 Gb) movie data sets and to track clathrin-mediated endocytosis (CME) events. We then expressed fluorescent protein fusions of actin and tubulin in genome-edited induced human pluripotent stem cells, which were differentiated into human cortical organoids. Using the AO-LLSM mode on the new MOSAIC (Multimodal Optical Scope with Adaptive Imaging Correction) allowed us to image neuronal migration deep in the organoid. We augmented pyLattice with a deep learning module and used it to process the brain organoid data.

January 23, 2020

1pm - 2pm
154 BSRB

Dan Cohn, PhD
Professor, Molecular, Cell & Developmental Biology and Orthopaedics Surgery

"The TRPV4 Skeletal Dysplasias: Genetics, Mechanism, Mouse Models and Prospects for Therapy"

OHRC Musculoskeletal Research Seminar Series
Seminar title: The TRPV4 Skeletal Dysplasias: Genetics, Mechanism, Mouse Models and Prospects for Therapy

Speaker: Dan Cohn, PhD
Professor, Molecular, Cell & Developmental Biology
and Orthopaedics Surgery,
UCLA College of Letters & Sciences,
David Geffen School of Medicine at UCLA
Contact – Gloria Kiel – gskiel@mednet.ucla.edu

January 23, 2020

5pm - 6pm
27-200C CHS

Andrew Goldstein, PhD
Assistant Professor-in-Residence, Molecular, Cell & Developmental Biology and Urology; UCLA College of Letters & Sciences and David Geffen School of Medicine at UCLA

"Prostate Aging, Tumorigenesis and Metabolism"