The Orthopaedic Hospital Research Center (OHRC) was formed in 2007 under the direction of John S. Adams, M.D. The aim of the OHRC is to create an interdisciplinary (Departments of Orthopaedic Surgery, Molecular Cell and Developmental Biology, Medicine, Broad Stem Cell Institute, etc.), interschool (medical, dental, engineering, etc.) research effort targeted at understanding and treating the most vexing issues in human musculoskeletal disease. Within this framework, the Adams laboratory is dedicated to an understanding of the molecular motive action of vitamin D as both a hormonal regulator of bone and mineral homeostasis as well as a locally-functioning monokine modulating the innate and adaptive immune response in infectious and autoimmune diseases affecting humans. Specifically, we investigate naturally-occurring experiments of nature in human and subhuman primates and transgenic mouse models of those experiments to better understand the means by which vitamin D and other steroid hormones (e.g. estrogen) control gene expression. On a more clinical-translational level we study the consequences of vitamin D insufficiency on the state of immunoreactivity and bone balance in the human host.
Dr. Adams is board certified in internal medicine and endocrinology, diabetes and metabolism. Dr. Adams has focused his research on sterol synthesis and metabolism, vitamin D and steroid hormone action, and osteoporosis. His research has been published in numerous peer-reviewed journals, including Nature, Science, Cell, Endocrinology, Molecular Endocrinology, Journal of Clinical Endocrinology and Metabolism, Journal of of Clinical Investigation, Annals of Internal Medicine and The New England Journal of Medicine. Dr. Adams serves as Associate Editor for the Journal of Bone and Mineral Research and on the editorial board for the Journal of Clinical Endocrinology and Metabolism. Dr. Adams is an active member of several professional committees on the national scene. He currently serves on the Skeletal Biology Development and Disease, the Orthopedic Study Section for grant review at the National Institute for Arthritis and Musculoskeletal Diseases of the National Institutes of Health. Dr. Adams received his bachelor's degree from the University of Kansas and his medical degree from the University of Kansas School of Medicine. He completed his fellowship in endocrinology and internal medicine at Massachusetts General Hospital, Harvard Medical School.
Teles RMB, Graeber TG, Krutzik SR, Montoya D, Schenk M, Lee DJ, Komisopoulou E, Kelly-Scumpia K, Chun R, Sarno EN, Rea TH, Hewison M, Adams JS, Popper SJ, Relman DA, Bloom BR, Cheng G, Modlin RM. Type I interferon suppresses Type II interferon-triggered human antimicrobial responses. Science. 339:1448-53, 2013. PMCID:PMC 23449998., (2013).
Rosen, CJ, Adams, JS, Bikle, DD, Black, DM, Demay, M, Manson, JE, Murad, MH. The nonskeletal effects of vitamin D: an endocrine society scientific statement. Endo Rev. 33:456-492, 2012. PMCID: PMC3365859., (2012).
Fabri M, Stenger S, Shin D, Yuk J, Liu PT, Realegeno S, Lee H, Krutzik SR, Schenk M, Sieling PA, Teles R, Montoya D, Iyer SS, Bruns H, Lewinsohn DM, Hollis BW, Hewison M, Adams JS, Steinmeyer A, Zgel U, Cheng G, Jo E, Bloom BR, Modlin RL. Vitamin D is required for IFN-γ mediated antimicrobial activity of human macrophages. Sci Transl Med. 3:104ra102, 2011. PMCID: PMC3269210., (2011).
Edfeldt K, Liu PT, Chun R, Fabri M, Schenk M, Wheelwright M, Keegan C, Krutzik SR, Adams JS, Hewison M, Modlin RM. T-cell cytokines differentially control human monocyte antimicrobial response by regulating vitamin D metabolism. Proc Natl Acad Sci USA. 107:22593-22598, 2010. PMCID: PMC3012480., (2010).
Hewison M, Adams JS. Update in vitamin D. J Clin Endocrinol Metab. 95:471-478, 2010. PMCID: PMC2840860., (2010).
Liu PT, Stenger S, Li H, Wenzel L, Tan BH, Krutzik SR, Ochoa MT, Schauber J, Wu K, Meinken C, Kamen DL, Wagner M, Bals R, Steinmeyer A, Zugel A, Gallo RL, Eisenberg,D, Hewison M, Hollis, BW, Adams JS, Bloom BR, Modlin RL. Toll-like receptor triggering of a vitamin D-mediated human antimicrobial response. Science. 311:1770-1773, 2006., (2006).
Adams JS. Bound to work: the free hormone hypothesis revisited. Cell. 122:647-649, 2005., (2005).
Chen, H, Arbelle JE, Gacad MA, Allegretto EA, Adams JS. Vitamin D and gonadal steroid-resistant New World primate cells express an intracellular protein which competes with the estrogen receptor for binding to the estrogen response element. J Clin Invest. 99:769-775, 1997., (1997).
Gacad MA, Adams JS. Endogenous blockade of cellular 1,25-dihydroxyvitamin D-receptor binding in New World primate cells. J Clin Invest. 87:996-1001, 1991., (1991).
Adams JS, Gacad MA. Characterization of the 1-hydroxylation of vitamin D3 sterols by cultured alveolar macrophages from patients with sarcoidosis. J Exp Med. 161:755-765, 1985., (1985).
Adams JS, Sharma OP, Gacad MA, Singer FR. Metabolism of 25-hydroxyvitamin D3 by cultured pulmonary alveolar macrophages in sarcoidosis. J Clin Invest. 72:1856-1860, 1983., (1983).
Adams JS, Clemens TL, Parrish JA, Holick MF. Vitamin D synthesis and metabolism after ultraviolet irradiation of normal and vitamin-D-deficient subjects. N Engl J Med. 305:722-725, 1982., (1982).
Clemens TL, Adams JS, Henderson SL, Holick MF. Increased skin pigment reduces the capacity of the skin to synthesize vitamin D. Lancet. 1:74-76, 1982., (1982).
Slovik DM, Adams JS, Neer RM, Holick MF, Potts JT, Jr. Deficient production of 1,25-dihydroxyvitamin D in elderly osteoporotic patients. N Engl J Med. 305:372-374, 1981., (1981).
Wong GL, Lukert BP, Adams JS. Glucocorticoids increase osteoblast-like bone cell response to 1,25(OH)2D3. Nature. 285:254-257, 1980., (1980).