Ira Ira_Clark

Associate Director for the Minor in Biomedical Research

phone: 75679
office: 220A Hershey

Research Interests

Selected Publications

Andrews S., Snowflack D.R., Clark I.E., Gavis E.R., "Multiple mechanisms collaborate to repress nanos translation in the Drosophila ovary and embryo", RNA 17: 967-977 (2011).

Clark, I.E.*, Romero-Calderon, R.*, Olson, J.M., Jaworski, L., Lopatto, D. and Banerjee, U., "?Deconstructing? scientific research ? a practical and scalable pedagogical tool to provide evidence-based science instruction", PLoS Biology 7 (12): (2009).

Yun, J., Cao, J.H., Dodson, M.W., Clark, I.E., Kapahi, P., Chowdhury, R.B. and Guo, M., "Loss-of-function analysis suggests that Omi/HtrA2 is not an essential component of the pink1/parkin pathway in vivo", J. Neuroscience 28: 14500-14510 (2008).

Clark, I.E.*, Dodson, M.W.*, Jiang, C.*, Cao, J.H., Huh, J.R., Seol, J.H., Yoo, S.J., Hay, B.A. and Guo, M, "Drosophila pink1 is required for mitochondrial function and interacts genetically with parkin", Nature 441: 1162-1166 (2006).

Ye, B., Petritsch, C., Clark, I.E., Gavis, E.R., Jan, L.Y. and Jan, Y.N., "nanos and pumilio are essential for dendrite morphogenesis in Drosophila peripheral neurons", Current Biology 14: 314-321 (2004).

Forrest, K.M., Clark, I.E., Jain, R.A. and Gavis, E.R., "Temporal complexity within a translational regulatory element in nanos mRNA", Development 131: 5849-5857 (2004).

Clark, I.E.*, Dobi, K.C.*, Duchow, H.K.*, Vlasak, A.N. and Gavis, E.R., "A common translational control mechanism functions in axial patterning and neuroendocrine signalling in Drosophila", Development 129: 3325-3334 (2002).

Clark, I.E., Wyckoff, D. and Gavis, E.R., "Synthesis of the posterior determinant Nanos is spatially restricted by a novel cotranslational regulatory mechanism", Current Biology 10: 1311-1314 (2000).

Clark, I.E., Jan. L.Y. and Jan, Y.N., "Reciprocal localization of Nod and kinesin fusion proteins indicates microtubule polarity in the Drosophila oocyte, epithelium, neuron and muscle", Development 124: 461-470 (1997).

Clark, I., Giniger, E., Ruohola-Baker, H., Jan, L.Y. and Jan, Y.N., "Transient posterior localization of a kinesin fusion protein reflects anteroposterior polarity of the Drosophila oocyte", Current Biology 4: 289-300 (1994).

Wang, H., Clark, I., Nicholson, P.R., Herskowitz, I. and Stillman, D., "The Saccharomyces cerevisiae SIN3 gene, a negative regulator of HO, contains four paired amphipathic helix motifs", Molecular and Cellular Biology 10: 5927-5936 (1990).

Sternberg, P.W., Stern, M.J., Clark, I. and Herskowitz, I., "Activation of the yeast HO gene by release from multiple negative controls", Cell 48: 567-577 (1987).